Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2124469..2124883 | Replicon | chromosome |
| Accession | NZ_CP082789 | ||
| Organism | Staphylococcus aureus strain HL24830 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | K3B00_RS10630 | Protein ID | WP_001065046.1 |
| Coordinates | 2124632..2124883 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | K3B00_RS10625 | Protein ID | WP_000028424.1 |
| Coordinates | 2124469..2124642 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3B00_RS10565 (2120033) | 2120033..2120377 | - | 345 | WP_000817289.1 | HNH endonuclease | - |
| K3B00_RS10570 (2120393) | 2120393..2120845 | - | 453 | WP_000406191.1 | nucleoside triphosphate pyrophosphohydrolase family protein | - |
| K3B00_RS10575 (2120960) | 2120960..2121430 | - | 471 | WP_000282758.1 | hypothetical protein | - |
| K3B00_RS10580 (2121453) | 2121453..2121653 | - | 201 | WP_000265041.1 | DUF1514 family protein | - |
| K3B00_RS10585 (2121653) | 2121653..2122303 | - | 651 | WP_001005262.1 | hypothetical protein | - |
| K3B00_RS10590 (2122462) | 2122462..2122611 | - | 150 | WP_000595305.1 | transcriptional activator RinB | - |
| K3B00_RS10595 (2122608) | 2122608..2122994 | - | 387 | WP_000592201.1 | hypothetical protein | - |
| K3B00_RS10600 (2122991) | 2122991..2123197 | - | 207 | WP_000195803.1 | DUF1381 domain-containing protein | - |
| K3B00_RS10605 (2123194) | 2123194..2123439 | - | 246 | WP_001282074.1 | hypothetical protein | - |
| K3B00_RS10610 (2123476) | 2123476..2124009 | - | 534 | WP_001061838.1 | dUTPase | - |
| K3B00_RS10615 (2124024) | 2124024..2124185 | - | 162 | WP_000889682.1 | hypothetical protein | - |
| K3B00_RS10620 (2124186) | 2124186..2124440 | - | 255 | WP_223297745.1 | hypothetical protein | - |
| K3B00_RS10625 (2124469) | 2124469..2124642 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| K3B00_RS10630 (2124632) | 2124632..2124883 | - | 252 | WP_001065046.1 | DUF1024 family protein | Toxin |
| K3B00_RS10635 (2124898) | 2124898..2125140 | - | 243 | WP_000131381.1 | phi PVL orf 51-like protein | - |
| K3B00_RS10640 (2125144) | 2125144..2125512 | - | 369 | WP_000101270.1 | SA1788 family PVL leukocidin-associated protein | - |
| K3B00_RS10645 (2125525) | 2125525..2125980 | - | 456 | WP_000401965.1 | RusA family crossover junction endodeoxyribonuclease | - |
| K3B00_RS10650 (2125989) | 2125989..2126207 | - | 219 | WP_000338527.1 | hypothetical protein | - |
| K3B00_RS10655 (2126214) | 2126214..2127107 | - | 894 | WP_000148327.1 | DnaD domain-containing protein | - |
| K3B00_RS10660 (2127137) | 2127137..2127607 | - | 471 | WP_000934762.1 | single-stranded DNA-binding protein | - |
| K3B00_RS10665 (2127608) | 2127608..2128225 | - | 618 | WP_072353921.1 | MBL fold metallo-hydrolase | - |
| K3B00_RS10670 (2128306) | 2128306..2129226 | - | 921 | WP_000138475.1 | recombinase RecT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / sak / hlb / sell / sec / tsst-1 / groEL | 2096119..2164718 | 68599 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9377.26 Da Isoelectric Point: 3.7128
>T215065 WP_001065046.1 NZ_CP082789:c2124883-2124632 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T215065 NZ_CP110389:6291865-6292146 [Rhodopseudomonas sp. P2A-2r]
GTGATCAAGAGTTTCAAAATCCGGATGACACAGGCGGCATTTGACGGAGAGGCTCTCAAGGGCTTTCCGGCTGCTCTGCT
GAAGGTGACGCGACGGCGATTGAACTATCTGGACTCGGCGACCTCGCTGCACGATTTGCAATCTCCGCCTGGAAATCGAC
TGGAGGCCTTGAAAGGAGACCGTCAGGGCCAACATTCGATCCGTGTGAACGATCAGTTCAGGATCTGCTTTGTCTGGACC
TCGGAAGGTCCGACGGATGTGGAATTTGTCGATTACCACTGA
GTGATCAAGAGTTTCAAAATCCGGATGACACAGGCGGCATTTGACGGAGAGGCTCTCAAGGGCTTTCCGGCTGCTCTGCT
GAAGGTGACGCGACGGCGATTGAACTATCTGGACTCGGCGACCTCGCTGCACGATTTGCAATCTCCGCCTGGAAATCGAC
TGGAGGCCTTGAAAGGAGACCGTCAGGGCCAACATTCGATCCGTGTGAACGATCAGTTCAGGATCTGCTTTGTCTGGACC
TCGGAAGGTCCGACGGATGTGGAATTTGTCGATTACCACTGA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT215065 WP_000028424.1 NZ_CP082789:c2124642-2124469 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT215065 NZ_CP110389:6292190-6292477 [Rhodopseudomonas sp. P2A-2r]
ATGCATCCCGGAGAAGTGTTGCGCGAGGAATTTCTTGTTCCGCTCGGGCTGTCCGCCGGCGGCCTTGCGAAGGCTTGCGG
CGTCCCCCGCACCCGAATCGAGCGGCTAGCCAATGAAGAGGCCGGCATCACCGCGGACACCGCCCTCCGGCTTGGAAAGG
CGCTCGACACGTCGGCACAGCTCTGGCTCAATTTGCAGAACGCCTACGATATGCGGATGGCCGAACGTCATATCGGCAAG
GAACTAGAGAAGATTTCTCCGGTGACACGCTCAGCGGCTGCGGCCTGA
ATGCATCCCGGAGAAGTGTTGCGCGAGGAATTTCTTGTTCCGCTCGGGCTGTCCGCCGGCGGCCTTGCGAAGGCTTGCGG
CGTCCCCCGCACCCGAATCGAGCGGCTAGCCAATGAAGAGGCCGGCATCACCGCGGACACCGCCCTCCGGCTTGGAAAGG
CGCTCGACACGTCGGCACAGCTCTGGCTCAATTTGCAGAACGCCTACGATATGCGGATGGCCGAACGTCATATCGGCAAG
GAACTAGAGAAGATTTCTCCGGTGACACGCTCAGCGGCTGCGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|