Detailed information of TA system TA215062

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2099750..2100057
• Replicon: chromosome
• Accession: NZ_CP082789
• Organism: Staphylococcus aureus strain HL24830

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: K3B00_RS10460
• Protein ID: WP_072353918.1
• Coordinates: 2099881..2100057 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2099750..2099889 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3B00_RS10420 (2095316)	2095316..2095495	+	180	WP_000669791.1	hypothetical protein	-
K3B00_RS10425 (2095806)	2095806..2096066	+	261	WP_001791826.1	hypothetical protein	-
K3B00_RS10430 (2096119)	2096119..2096469	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
K3B00_RS10435 (2096980)	2096980..2097315	-	336	Protein_2034	SH3 domain-containing protein	-
K3B00_RS10440 (2097966)	2097966..2098457	-	492	WP_000920038.1	staphylokinase	-
K3B00_RS10445 (2098648)	2098648..2099403	-	756	WP_000861038.1	CHAP domain-containing protein	-
K3B00_RS10450 (2099415)	2099415..2099669	-	255	WP_000611512.1	phage holin	-
K3B00_RS10455 (2099721)	2099721..2099828	+	108	WP_001791821.1	hypothetical protein	-
- (2099750)	2099750..2099889	+	140	NuclAT_0	-	Antitoxin
- (2099750)	2099750..2099889	+	140	NuclAT_0	-	Antitoxin
- (2099750)	2099750..2099889	+	140	NuclAT_0	-	Antitoxin
- (2099750)	2099750..2099889	+	140	NuclAT_0	-	Antitoxin
K3B00_RS10460 (2099881)	2099881..2100057	-	177	WP_072353918.1	type I toxin-antitoxin system toxin PepG1	Toxin
K3B00_RS10465 (2100200)	2100200..2100574	-	375	WP_000340977.1	hypothetical protein	-
K3B00_RS10470 (2100630)	2100630..2100917	-	288	WP_001262620.1	hypothetical protein	-
K3B00_RS10475 (2100963)	2100963..2101115	-	153	WP_001000058.1	hypothetical protein	-
K3B00_RS10480 (2101108)	2101108..2104890	-	3783	WP_000582132.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / sell / sec / tsst-1 / groEL	2096119..2164718	68599

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T215062 WP_072353918.1 NZ_CP082789:c2100057-2099881 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T215062 NZ_CP110389:c5043337-5043044 [Rhodopseudomonas sp. P2A-2r]
ATGATCGTGGGTTTTCGCGACGCATGGCTGCGGGCTTTCTTCGTAGACGATGTCCGCTCCCGGAATATTCCGGCAGACAT
CGAAAGCCGGCTGTTTCGTAAATTGCAGATGATCGATGACGCGACGACCGATCAGGATTTGCGCGTTCCGCCCAGCAATC
ATTTCGAGAAGCTGCGGGGCAGGCTGAGCGGCTTTCATTCGATTCGCATCAACGACCAATGGCGGCTGATCTTCCGGTGG
GGCGGCCAGGGTGAAGCGTCGGACATCTATCTGGACGATCACAGCTACCGATGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT215062 NZ_CP082789:2099750-2099889 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin