Detailed information of TA system TA215056

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1609849..1610428
• Replicon: chromosome
• Accession: NZ_CP082789
• Organism: Staphylococcus aureus strain HL24830

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: K3B00_RS07810
• Protein ID: WP_001025401.1
• Coordinates: 1610183..1610428 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1609849..1610214 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3B00_RS07770 (1606593)	1606593..1607150	-	558	WP_000645045.1	DUF2815 family protein	-
K3B00_RS07775 (1607176)	1607176..1608342	-	1167	WP_000762525.1	DUF2800 domain-containing protein	-
K3B00_RS07780 (1608339)	1608339..1608701	-	363	WP_000279445.1	hypothetical protein	-
K3B00_RS07785 (1608716)	1608716..1609039	-	324	WP_000174995.1	hypothetical protein	-
K3B00_RS07790 (1609118)	1609118..1609279	-	162	WP_015986189.1	DUF1270 family protein	-
K3B00_RS07795 (1609291)	1609291..1609554	-	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
K3B00_RS07800 (1609579)	1609579..1609794	-	216	WP_001097552.1	hypothetical protein	-
K3B00_RS07805 (1609849)	1609849..1610214	+	366	WP_001128433.1	hypothetical protein	Antitoxin
K3B00_RS07810 (1610183)	1610183..1610428	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
K3B00_RS07815 (1610484)	1610484..1610693	+	210	WP_000642492.1	hypothetical protein	-
K3B00_RS07820 (1610683)	1610683..1610826	-	144	WP_000939498.1	hypothetical protein	-
K3B00_RS07825 (1610841)	1610841..1611284	-	444	WP_044414793.1	hypothetical protein	-
K3B00_RS07830 (1611308)	1611308..1611529	-	222	WP_031887876.1	DUF739 family protein	-
K3B00_RS07835 (1611690)	1611690..1612460	+	771	WP_031887877.1	S24 family peptidase	-
K3B00_RS07840 (1612472)	1612472..1612618	+	147	WP_001049401.1	hypothetical protein	-
K3B00_RS07845 (1612615)	1612615..1612800	+	186	WP_000109189.1	hypothetical protein	-
K3B00_RS07850 (1612870)	1612870..1613037	+	168	WP_000705241.1	hypothetical protein	-
K3B00_RS07855 (1613177)	1613177..1613881	+	705	WP_000440838.1	type II toxin-antitoxin system PemK/MazF family toxin	-
K3B00_RS07860 (1614092)	1614092..1615297	+	1206	WP_031766111.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	gnd	1571061..1637882	66821

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T215056 WP_001025401.1 NZ_CP082789:c1610428-1610183 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T215056 NZ_CP110376:c4088523-4087210 [Proteus mirabilis]
ATGGCGAGTCTTGATGTATATATGAATGAATACTATGTGGGCATCTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAACCAGGAAGTCGTCCCATCTCTCTTTCGATGCCATTACAGCTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTGTTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAACTCAAATCAACCCTTTGACCTATTAGCGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
CAGTACGCCTGCGGATATCAAAAAAATAGAATATCAAAAACTCAATGATACTGAGCTTGAAAAAATTCTACTAGGATATA
AATCCAATACTCCACTCGGTATGCTTAAAGAATATACTGATTTCAGAATTTCCATCGCTGGAGCACAAGAAAAAACGGCA
TTACTTTTAAAAGATAATCATTGGTGTGTGCCACATAATAACACACCAACTACCCATATTATTAAACTGCCAATTGGTGT
TATTGAAAGTCATTCTTATACAATGGATTTATCCAATAGTGTAGAAAATGAGTATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCCGTCCCCCACTGCTCTATTATTAAAACAAAAAATGTTAAAGCGCTTGCTGTAGAACGTTTCGATAGAAAA
TATTCATCTGATAAATCGTGGATAATACGTTTACCTCAAGAAGATTTTTGCCAAATTTTAAATATACCTTCTGCGCTAAA
ATATGAAAATGAAGGAGGGCCTGGCATTATCGATATTATGAAATATTTACTTGGTTCATCAAATGCCGATCAAGATCGTT
TTCATTTTATGAAGGCACAAGTGCTATTTTGGCTTTTGGCTGCAACGGATGGACACGCAAAGAATTTTTCTGTTTTTATC
AACCAAGAAGGACGTTTCCATCTCACTCCCCTTTATGACATTATGTCCATCTATCCCAATTTCGGAGGACGAGGACTTAA
TCCACGAGATGCAAAACTTGCTATGGGATTAAAAGCAAGCCGAGGCAAAAAATACGCAATAGAACAAATTTTTCCTCGTC
ATTTCTACCAAACAGCTGAAGCTGTCGGTTTCGATCCTTCATTAATGAGCGATATTCTTCGTTATTTTTATCAAGAAATG
GACGATGTCATACAACGCGTAAAACAGCAATTACCCGAGGATTTCCCTTCTGAGATTAGCAATACAATATTAGATGGAAT
GAAAGCACGCGCTGTTAGATTAGCTAACATTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT215056 NZ_CP082789:1609849-1610214 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin