Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4404385..4405115 Replicon chromosome
Accession NZ_CP082787
Organism Serratia entomophila strain A1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KHA73_RS21135 Protein ID WP_234591346.1
Coordinates 4404385..4404696 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KHA73_RS21140 Protein ID WP_234586471.1
Coordinates 4404693..4405115 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHA73_RS21105 (KHA73_21115) 4399741..4400466 + 726 WP_234586462.1 LPS export ABC transporter ATP-binding protein -
KHA73_RS21110 (KHA73_21120) 4400517..4401950 + 1434 WP_234586464.1 RNA polymerase factor sigma-54 -
KHA73_RS21115 (KHA73_21125) 4401974..4402261 + 288 WP_004937038.1 ribosome hibernation promoting factor -
KHA73_RS21120 (KHA73_21130) 4402421..4402882 + 462 WP_234586466.1 PTS IIA-like nitrogen regulatory protein PtsN -
KHA73_RS21125 (KHA73_21135) 4403014..4403868 + 855 WP_234586468.1 RNase adapter RapZ -
KHA73_RS21130 (KHA73_21140) 4403865..4404137 + 273 WP_234586470.1 PTS phosphocarrier protein NPr -
KHA73_RS21135 (KHA73_21145) 4404385..4404696 + 312 WP_234591346.1 type II toxin-antitoxin system HigB family toxin Toxin
KHA73_RS21140 (KHA73_21150) 4404693..4405115 + 423 WP_234586471.1 helix-turn-helix domain-containing protein Antitoxin
KHA73_RS21145 (KHA73_21155) 4405198..4405593 - 396 WP_095099419.1 hypothetical protein -
KHA73_RS21150 (KHA73_21160) 4405615..4406688 - 1074 WP_231922104.1 hypothetical protein -
KHA73_RS21155 (KHA73_21165) 4406751..4408667 - 1917 WP_234586473.1 PRD domain-containing protein -
KHA73_RS21160 (KHA73_21170) 4408718..4409932 - 1215 WP_234586475.1 lactonase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Antitoxin HigA

(2-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12253.09 Da        Isoelectric Point: 9.3944

>T215052 WP_234591346.1 NZ_CP082787:4404385-4404696 [Serratia entomophila]
MHIISREPFNHAAKQYPNEEAALDAVYKTLRRGSFNTPDDLKALFPSLDRMKYRAKWWVIDIGGNNLRMLFFASFDTQKI
FVKHIVCHAEYDKLMQLYQRNQE

Download         Length: 312 bp

>T215052 NZ_CP110376:c1557342-1557157 [Proteus mirabilis]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15810.15 Da        Isoelectric Point: 5.2453

>AT215052 WP_234586471.1 NZ_CP082787:4404693-4405115 [Serratia entomophila]
MISDAIKATQELLRAVPLLRGSTSQQDYREALELVEHLLETDEHNPLIDLLAAKIAEFEESSPDFAEFNLRQRQLPQGVA
ALSVLMEQHQLSQRDFENEIGKKSLVSQILNGKRSLTIPHIMALAKRFNLPPAIFLPEAR

Download         Length: 423 bp

>AT215052 NZ_CP110376:c1557110-1556697 [Proteus mirabilis]
ATGTTATATCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References