Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 4618045..4618267 Replicon chromosome
Accession NZ_CP082776
Organism Escherichia coli O4:H5 strain CU532-9

Toxin (Protein)


Gene name ldrD Uniprot ID A0A0D6GD35
Locus tag K8B92_RS22320 Protein ID WP_000170745.1
Coordinates 4618045..4618152 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 4618209..4618267 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B92_RS22295 4613298..4614050 - 753 WP_000279525.1 cellulose biosynthesis protein BcsQ -
K8B92_RS22300 4614062..4614250 - 189 WP_001063314.1 cellulose biosynthesis protein BcsR -
K8B92_RS22305 4614523..4616094 + 1572 WP_001204945.1 cellulose biosynthesis c-di-GMP-binding protein BcsE -
K8B92_RS22310 4616091..4616282 + 192 WP_000988311.1 cellulose biosynthesis protein BcsF -
K8B92_RS22315 4616279..4617958 + 1680 WP_000191567.1 cellulose biosynthesis protein BcsG -
K8B92_RS22320 4618045..4618152 - 108 WP_000170745.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 4618209..4618267 + 59 - - Antitoxin
K8B92_RS22325 4618628..4619899 + 1272 WP_001467807.1 amino acid permease -
K8B92_RS22330 4619929..4620933 - 1005 WP_000103583.1 dipeptide ABC transporter ATP-binding subunit DppF -
K8B92_RS22335 4620930..4621913 - 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
K8B92_RS22340 4621924..4622826 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3855.68 Da        Isoelectric Point: 9.0157

>T214988 WP_000170745.1 NZ_CP082776:c4618152-4618045 [Escherichia coli O4:H5]
MTLAELGMAFWHDLAAPVIAGILASMIVSWLNKRK

Download         Length: 108 bp

>T214988 NZ_CP110354:c1107925-1107707 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 59 bp

>AT214988 NZ_CP082776:4618209-4618267 [Escherichia coli O4:H5]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6GD35

Antitoxin

Download structure file

References