Detailed information of TA system TA214969

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 807465..807723
• Replicon: chromosome
• Accession: NZ_CP082776
• Organism: Escherichia coli O4:H5 strain CU532-9

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: K8B92_RS03845
• Protein ID: WP_000809168.1
• Coordinates: 807465..807617 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	807666..807723 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B92_RS03825	802709..803422	-	714	WP_001102393.1	acidic protein MsyB	-
K8B92_RS03830	803448..803852	-	405	WP_000843687.1	DUF2541 family protein	-
K8B92_RS03835	804225..806141	+	1917	WP_000516135.1	molecular chaperone DnaK	-
K8B92_RS03840	806230..807360	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
K8B92_RS03845	807465..807617	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	807666..807723	+	58	-	-	Antitoxin
K8B92_RS03850	808232..808993	+	762	WP_001274832.1	outer membrane protein OmpK	-
K8B92_RS03855	809013..810506	+	1494	WP_001468392.1	sulfatase-like hydrolase/transferase	-
K8B92_RS03860	810635..811894	+	1260	WP_000494928.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T214969 WP_000809168.1 NZ_CP082776:c807617-807465 [Escherichia coli O4:H5]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T214969 NZ_CP110351:1572494-1573249 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAACTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT214969 NZ_CP082776:807666-807723 [Escherichia coli O4:H5]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin