Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2211950..2212213 Replicon chromosome
Accession NC_007795
Organism Staphylococcus aureus subsp. aureus NCTC 8325

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag SAOUHSC_02391 Protein ID YP_500868.1
Coordinates 2212109..2212213 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2211950..2212114 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAOUHSC_02386 2207609..2207833 - 225 YP_500863.1 hypothetical protein -
SAOUHSC_02387 2208190..2208855 - 666 YP_500864.1 hypothetical protein -
SAOUHSC_02388 2209007..2209327 + 321 YP_500865.1 hypothetical protein -
SAOUHSC_02389 2209329..2210309 + 981 YP_500866.1 cation efflux family protein -
SAOUHSC_02390 2210575..2211666 + 1092 YP_500867.1 lytic regulatory protein -
- 2211950..2212114 + 165 - - Antitoxin
SAOUHSC_02391 2212109..2212213 - 105 YP_500868.1 hypothetical protein Toxin
SAOUHSC_02393 2212900..2214036 - 1137 YP_500870.1 hypothetical protein -
SAOUHSC_02394 2214325..2214417 + 93 YP_500871.1 hypothetical protein -
SAOUHSC_02396 2215122..2215979 - 858 YP_500873.1 hypothetical protein -
SAOUHSC_02397 2216047..2216829 - 783 YP_500874.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-133)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T21493 YP_500868.1 NC_007795:c2212213-2212109 [Staphylococcus aureus subsp. aureus NCTC 8325]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T21493 NC_007795:c2212213-2212109 [Staphylococcus aureus subsp. aureus NCTC 8325]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT21493 NC_007795:2211950-2212114 [Staphylococcus aureus subsp. aureus NCTC 8325]
GTAGCAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2FWA7

Antitoxin

Download structure file

References