Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 2969431..2969933 | Replicon | chromosome |
Accession | NZ_CP082773 | ||
Organism | Escherichia coli O99:H6 strain CU42ET-1 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | - |
Locus tag | K8B87_RS14440 | Protein ID | WP_001560606.1 |
Coordinates | 2969431..2969685 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | S1Q063 |
Locus tag | K8B87_RS14445 | Protein ID | WP_001259255.1 |
Coordinates | 2969682..2969933 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K8B87_RS14410 (2964446) | 2964446..2964673 | - | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
K8B87_RS14415 (2964687) | 2964687..2965745 | - | 1059 | WP_042343276.1 | thiosulfate utilization transporter TsuA/YeeE | - |
K8B87_RS14420 (2965924) | 2965924..2967282 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
K8B87_RS14425 (2967272) | 2967272..2967334 | - | 63 | WP_097433929.1 | membrane protein YoeI | - |
K8B87_RS14430 (2967549) | 2967549..2968478 | - | 930 | WP_023565113.1 | LysR substrate-binding domain-containing protein | - |
K8B87_RS14435 (2968524) | 2968524..2969348 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
K8B87_RS14440 (2969431) | 2969431..2969685 | - | 255 | WP_001560606.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
K8B87_RS14445 (2969682) | 2969682..2969933 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
K8B87_RS14450 (2970216) | 2970216..2970266 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
K8B87_RS14455 (2970412) | 2970412..2971311 | + | 900 | WP_087602615.1 | ATP phosphoribosyltransferase | - |
K8B87_RS14460 (2971317) | 2971317..2972621 | + | 1305 | WP_087602616.1 | histidinol dehydrogenase | - |
K8B87_RS14465 (2972618) | 2972618..2973688 | + | 1071 | WP_023565116.1 | histidinol-phosphate transaminase | - |
K8B87_RS14470 (2973688) | 2973688..2974755 | + | 1068 | WP_023565117.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10153.60 Da Isoelectric Point: 8.8560
>T214907 WP_001560606.1 NZ_CP082773:c2969685-2969431 [Escherichia coli O99:H6]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEVHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEVHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T214907 NZ_CP110339:c2207875-2207474 [Brucella sp. JSBI001]
ATGCTGAAGTACATGCTGGATACAAATATATGCATTTTCACGATCAAGAACCGGCCGCAGCAAGTGCGCGAGGCGTTCAA
CCGCTTCCACGATCAATTGTGCATCAGCTCAGTCAGTTTAATGGAGCTGATTTACGGGGCGGAGAAGTCTGCCCATCCTG
AAAAGAACCTTGCAGTCGTGGAAGGGTTCGCAGCTCGCCTTGAGGTGTTATCGTATGATGAACCGGCAGCAAACCATACG
GGCCAATTACGTGCTGAATTGGCCCGCAGTGGAACTCCAATCGGTCCATACGATCAATTGATTGCTGGCCATGCTCGCTC
GCGTGGCCTGATAATCGTTACAAACAATCGCACGGAATTTGATCGTGTTCCTGGCTTGCGAGTAGAAGACTGGACTGATT
AA
ATGCTGAAGTACATGCTGGATACAAATATATGCATTTTCACGATCAAGAACCGGCCGCAGCAAGTGCGCGAGGCGTTCAA
CCGCTTCCACGATCAATTGTGCATCAGCTCAGTCAGTTTAATGGAGCTGATTTACGGGGCGGAGAAGTCTGCCCATCCTG
AAAAGAACCTTGCAGTCGTGGAAGGGTTCGCAGCTCGCCTTGAGGTGTTATCGTATGATGAACCGGCAGCAAACCATACG
GGCCAATTACGTGCTGAATTGGCCCGCAGTGGAACTCCAATCGGTCCATACGATCAATTGATTGCTGGCCATGCTCGCTC
GCGTGGCCTGATAATCGTTACAAACAATCGCACGGAATTTGATCGTGTTCCTGGCTTGCGAGTAGAAGACTGGACTGATT
AA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT214907 WP_001259255.1 NZ_CP082773:c2969933-2969682 [Escherichia coli O99:H6]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT214907 NZ_CP110339:c2208105-2207875 [Brucella sp. JSBI001]
ATGGAGCAGGGAGCAGTATTCCAGAGCAACCGGAGCCAAGCTATCCGCTTGCCAAAAGCAGTAGCATTGCCTGCTGATGT
GAAACGCGTTGATATTGTTGCTGTGGGGCGCACTCGAATCATAGCACCCGCTGGTGAGGTCTGGGATAGCTGGTTTGATA
GCTTAGAGGCGACTTCCGACTTCATGAATGAGCGTGATCAGCCTGCTCCACAGGAACGCGAGGCGTTCTAA
ATGGAGCAGGGAGCAGTATTCCAGAGCAACCGGAGCCAAGCTATCCGCTTGCCAAAAGCAGTAGCATTGCCTGCTGATGT
GAAACGCGTTGATATTGTTGCTGTGGGGCGCACTCGAATCATAGCACCCGCTGGTGAGGTCTGGGATAGCTGGTTTGATA
GCTTAGAGGCGACTTCCGACTTCATGAATGAGCGTGATCAGCCTGCTCCACAGGAACGCGAGGCGTTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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