Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 173911..174513 | Replicon | chromosome |
Accession | NZ_CP082773 | ||
Organism | Escherichia coli O99:H6 strain CU42ET-1 |
Toxin (Protein)
Gene name | higB | Uniprot ID | S1P416 |
Locus tag | K8B87_RS00840 | Protein ID | WP_000897302.1 |
Coordinates | 173911..174222 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | K8B87_RS00845 | Protein ID | WP_000356397.1 |
Coordinates | 174223..174513 (+) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K8B87_RS00815 (169825) | 169825..170424 | + | 600 | WP_001314324.1 | glucose-1-phosphatase | - |
K8B87_RS00820 (170418) | 170418..171290 | + | 873 | WP_000920762.1 | virulence factor BrkB family protein | - |
K8B87_RS00825 (171287) | 171287..171724 | + | 438 | WP_001553787.1 | D-aminoacyl-tRNA deacylase | - |
K8B87_RS00830 (171769) | 171769..172710 | + | 942 | WP_001297068.1 | fatty acid biosynthesis protein FabY | - |
K8B87_RS00835 (172774) | 172774..173682 | - | 909 | WP_087602929.1 | alpha/beta hydrolase | - |
K8B87_RS00840 (173911) | 173911..174222 | + | 312 | WP_000897302.1 | hypothetical protein | Toxin |
K8B87_RS00845 (174223) | 174223..174513 | + | 291 | WP_000356397.1 | NadS family protein | Antitoxin |
K8B87_RS00850 (174872) | 174872..175150 | + | 279 | WP_234257669.1 | hypothetical protein | - |
K8B87_RS00855 (175546) | 175546..175764 | + | 219 | WP_001314326.1 | CopG family transcriptional regulator | - |
K8B87_RS00860 (175986) | 175986..176915 | - | 930 | WP_000027720.1 | formate dehydrogenase accessory protein FdhE | - |
K8B87_RS00865 (176912) | 176912..177547 | - | 636 | WP_000829013.1 | formate dehydrogenase cytochrome b556 subunit | - |
K8B87_RS00870 (177544) | 177544..178446 | - | 903 | WP_000331377.1 | formate dehydrogenase O subunit beta | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12203.19 Da Isoelectric Point: 9.7791
>T214885 WP_000897302.1 NZ_CP082773:173911-174222 [Escherichia coli O99:H6]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
Download Length: 312 bp
>T214885 NZ_CP110306:c4425200-4425048 [Xanthomonas phaseoli pv. phaseoli]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGTCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAGTGCAGCGACGGTAAGTGCTGA
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGTCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAGTGCAGCGACGGTAAGTGCTGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10846.43 Da Isoelectric Point: 10.8907
>AT214885 WP_000356397.1 NZ_CP082773:174223-174513 [Escherichia coli O99:H6]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
Download Length: 291 bp
>AT214885 NZ_CP110306:c4424973-4424839 [Xanthomonas phaseoli pv. phaseoli]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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