214879

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3201146..3201648 Replicon chromosome
Accession NZ_CP082772
Organism Escherichia coli O2:H1 strain HM670

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag K8B93_RS15700 Protein ID WP_000767822.1
Coordinates 3201146..3201400 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag K8B93_RS15705 Protein ID WP_001259255.1
Coordinates 3201397..3201648 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B93_RS15680 (3197639) 3197639..3198997 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
K8B93_RS15685 (3198987) 3198987..3199049 - 63 WP_010723108.1 membrane protein YoeI -
K8B93_RS15690 (3199264) 3199264..3200193 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
K8B93_RS15695 (3200239) 3200239..3201063 - 825 WP_000754733.1 SDR family oxidoreductase -
K8B93_RS15700 (3201146) 3201146..3201400 - 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
K8B93_RS15705 (3201397) 3201397..3201648 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
K8B93_RS15710 (3201931) 3201931..3201981 + 51 WP_001364200.1 his operon leader peptide -
K8B93_RS15715 (3202127) 3202127..3203026 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
K8B93_RS15720 (3203032) 3203032..3204336 + 1305 WP_001617113.1 histidinol dehydrogenase -
K8B93_RS15725 (3204333) 3204333..3205403 + 1071 WP_000108943.1 histidinol-phosphate transaminase -
K8B93_RS15730 (3205403) 3205403..3206470 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T214879 WP_000767822.1 NZ_CP082772:c3201400-3201146 [Escherichia coli O2:H1]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T214879 NZ_CP110303:c4487958-4487824 [Xanthomonas phaseoli pv. phaseoli]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT214879 WP_001259255.1 NZ_CP082772:c3201648-3201397 [Escherichia coli O2:H1]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT214879 NZ_CP110303:c4488185-4488033 [Xanthomonas phaseoli pv. phaseoli]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGTCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAGTGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References