Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 174999..175601 | Replicon | chromosome |
Accession | NZ_CP082772 | ||
Organism | Escherichia coli O2:H1 strain HM670 |
Toxin (Protein)
Gene name | higB | Uniprot ID | S1P416 |
Locus tag | K8B93_RS00840 | Protein ID | WP_000897302.1 |
Coordinates | 174999..175310 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | K8B93_RS00845 | Protein ID | WP_000356397.1 |
Coordinates | 175311..175601 (+) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K8B93_RS00815 (170912) | 170912..171511 | + | 600 | WP_001443191.1 | glucose-1-phosphatase | - |
K8B93_RS00820 (171505) | 171505..172377 | + | 873 | WP_000920762.1 | virulence factor BrkB family protein | - |
K8B93_RS00825 (172374) | 172374..172811 | + | 438 | WP_000560983.1 | D-aminoacyl-tRNA deacylase | - |
K8B93_RS00830 (172856) | 172856..173797 | + | 942 | WP_001297068.1 | fatty acid biosynthesis protein FabY | - |
K8B93_RS00835 (173861) | 173861..174769 | - | 909 | WP_001305059.1 | alpha/beta hydrolase | - |
K8B93_RS00840 (174999) | 174999..175310 | + | 312 | WP_000897302.1 | hypothetical protein | Toxin |
K8B93_RS00845 (175311) | 175311..175601 | + | 291 | WP_000356397.1 | NadS family protein | Antitoxin |
K8B93_RS00850 (175960) | 175960..176238 | + | 279 | WP_001296612.1 | hypothetical protein | - |
K8B93_RS00855 (176634) | 176634..176852 | + | 219 | WP_001314326.1 | CopG family transcriptional regulator | - |
K8B93_RS00860 (177068) | 177068..177997 | - | 930 | WP_000027720.1 | formate dehydrogenase accessory protein FdhE | - |
K8B93_RS00865 (177994) | 177994..178629 | - | 636 | WP_000829013.1 | formate dehydrogenase cytochrome b556 subunit | - |
K8B93_RS00870 (178626) | 178626..179528 | - | 903 | WP_021528695.1 | formate dehydrogenase O subunit beta | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12203.19 Da Isoelectric Point: 9.7791
>T214854 WP_000897302.1 NZ_CP082772:174999-175310 [Escherichia coli O2:H1]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
Download Length: 312 bp
>T214854 NZ_CP110289:c2651373-2651230 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAGACAATTCAGACGATCCTAGGTTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAGACAATTCAGACGATCCTAGGTTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10846.43 Da Isoelectric Point: 10.8907
>AT214854 WP_000356397.1 NZ_CP082772:175311-175601 [Escherichia coli O2:H1]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
Download Length: 291 bp
>AT214854 NZ_CP110289:2651111-2651297 [Enterococcus faecalis]
TGTGCTAGAATGTAGATGAAAAGAGAGATATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGATGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA
TGTGCTAGAATGTAGATGAAAAGAGAGATATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGATGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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