Detailed information of TA system TA214832

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 816486..816744
• Replicon: chromosome
• Accession: NZ_CP082771
• Organism: Escherichia coli LF82

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: K8B90_RS03850
• Protein ID: WP_000809168.1
• Coordinates: 816486..816638 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	816687..816744 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B90_RS03830	811731..812444	-	714	WP_001102393.1	acidic protein MsyB	-
K8B90_RS03835	812470..812874	-	405	WP_000843689.1	DUF2541 family protein	-
K8B90_RS03840	813246..815162	+	1917	WP_000516135.1	molecular chaperone DnaK	-
K8B90_RS03845	815251..816381	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
K8B90_RS03850	816486..816638	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	816687..816744	+	58	-	-	Antitoxin
K8B90_RS03855	817253..818014	+	762	WP_001274832.1	outer membrane protein OmpK	-
K8B90_RS03860	818034..819527	+	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
K8B90_RS03865	819656..820915	+	1260	WP_000494928.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T214832 WP_000809168.1 NZ_CP082771:c816638-816486 [Escherichia coli LF82]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T214832 NZ_CP110265:c4548879-4548538 [Klebsiella pneumoniae]
ATGAATACTTTACCTGTAATAAACCAGCGGGCTATTCAGTTATGCCCATCGCCTGTAACTATCTGGCAAACGTTGCTAAC
TCGTTTACTGGAACAACACTACGGGCTGGCGCTGAACGACACACCGTTCGGTGATGAAAGCGTGATTCAGGAACATATCG
AGGCCGGTATTACACTCGTTGATGCCGTTAACTTCTTGGTGGAAAAGTACGAGCTGGTTCGTATCGACCGCTGGGCGTTT
GGCTGGTTGGAACCATCTCCATACTTGCGAGCTGAAGACATTCTGCGAATGCGTCGGGACATGGGGCTGTTGCGAGGCTG
CAACCACACTGCAGCAATGTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT214832 NZ_CP082771:816687-816744 [Escherichia coli LF82]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin