Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 745150..745925 Replicon chromosome
Accession NZ_CP082765
Organism Klebsiella pneumoniae strain 12

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag FTO26_RS03715 Protein ID WP_004150910.1
Coordinates 745440..745925 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag FTO26_RS03710 Protein ID WP_004150912.1
Coordinates 745150..745443 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTO26_RS03690 (FTO26_003690) 740358..740960 - 603 WP_062954968.1 short chain dehydrogenase -
FTO26_RS03695 (FTO26_003695) 741058..741969 + 912 WP_004188550.1 LysR family transcriptional regulator -
FTO26_RS03700 (FTO26_003700) 741970..743118 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
FTO26_RS03705 (FTO26_003705) 743129..744505 - 1377 WP_004217775.1 cystathionine beta-synthase -
FTO26_RS03710 (FTO26_003710) 745150..745443 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
FTO26_RS03715 (FTO26_003715) 745440..745925 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
FTO26_RS03720 (FTO26_003720) 746629..747222 + 594 WP_004188553.1 hypothetical protein -
FTO26_RS03725 (FTO26_003725) 747319..747535 + 217 Protein_733 transposase -
FTO26_RS03730 (FTO26_003730) 748141..749013 + 873 WP_004188557.1 ParA family protein -
FTO26_RS03735 (FTO26_003735) 749013..749396 + 384 WP_004150906.1 hypothetical protein -
FTO26_RS03740 (FTO26_003740) 749389..750756 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 747319..747471 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T214799 WP_004150910.1 NZ_CP082765:745440-745925 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T214799 NZ_CP110258:2353726-2354004 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT214799 WP_004150912.1 NZ_CP082765:745150-745443 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT214799 NZ_CP110258:2354004-2354288 [Escherichia albertii]
ATGAAAATGGTCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTGACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References