21477

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2530082..2530599 Replicon chromosome
Accession NC_007793
Organism Staphylococcus aureus subsp. aureus USA300 FPR3757

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag SAUSA300_RS12985 Protein ID WP_000113262.1
Coordinates 2530082..2530348 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag SAUSA300_RS12990 Protein ID WP_000584502.1
Coordinates 2530348..2530599 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAUSA300_RS12960 2525508..2526044 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
SAUSA300_RS12965 2526277..2527101 - 825 WP_000572040.1 formate/nitrite transporter family protein -
SAUSA300_RS12970 2527318..2527500 - 183 WP_000230294.1 hypothetical protein -
SAUSA300_RS12975 2527584..2528051 - 468 WP_000153344.1 SRPBCC domain-containing protein -
SAUSA300_RS12980 2528237..2529787 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAUSA300_RS15830 2529976..2530047 - 72 Protein_2467 hypothetical protein -
SAUSA300_RS12985 2530082..2530348 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
SAUSA300_RS12990 2530348..2530599 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAUSA300_RS12995 2530764..2530865 - 102 WP_001791744.1 hypothetical protein -
SAUSA300_RS13000 2530872..2531471 - 600 WP_000162813.1 DsbA family protein -
SAUSA300_RS13005 2531490..2531849 - 360 WP_000819847.1 DUF4467 domain-containing protein -
SAUSA300_RS13010 2532104..2533354 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
SAUSA300_RS13015 2533451..2534182 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
SAUSA300_RS13020 2534179..2534898 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T21477 WP_000113262.1 NC_007793:c2530348-2530082 [Staphylococcus aureus subsp. aureus USA300_FPR3757]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T21477 NC_007793:c2530348-2530082 [Staphylococcus aureus subsp. aureus USA300_FPR3757]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT21477 WP_000584502.1 NC_007793:c2530599-2530348 [Staphylococcus aureus subsp. aureus USA300_FPR3757]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT21477 NC_007793:c2530599-2530348 [Staphylococcus aureus subsp. aureus USA300_FPR3757]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References