Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2140135..2140795 Replicon chromosome
Accession NZ_CP082360
Organism Klebsiella sp. CTHL.F3a

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K7H21_RS10095 Protein ID WP_223035749.1
Coordinates 2140135..2140488 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K7H21_RS10100 Protein ID WP_142446694.1
Coordinates 2140493..2140795 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H21_RS10070 (K7H21_10070) 2135518..2136285 - 768 WP_004122251.1 molybdopterin-dependent oxidoreductase -
K7H21_RS10075 (K7H21_10075) 2136275..2136883 - 609 WP_223035747.1 cytochrome b/b6 domain-containing protein -
K7H21_RS10080 (K7H21_10080) 2136898..2137524 - 627 WP_112166276.1 hypothetical protein -
K7H21_RS10085 (K7H21_10085) 2137664..2138335 + 672 WP_004122240.1 heavy metal response regulator transcription factor -
K7H21_RS10090 (K7H21_10090) 2138332..2139750 + 1419 WP_223035748.1 heavy metal sensor histidine kinase -
K7H21_RS10095 (K7H21_10095) 2140135..2140488 + 354 WP_223035749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K7H21_RS10100 (K7H21_10100) 2140493..2140795 + 303 WP_142446694.1 XRE family transcriptional regulator Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13547.48 Da        Isoelectric Point: 9.4800

>T214726 WP_223035749.1 NZ_CP082360:2140135-2140488 [Klebsiella sp. CTHL.F3a]
VWMIKTTDTFERWFTSLNDTDRASVLAALLVLREKGPGLSRPYADTLRGSRYSNMKELRIQSRGEPIRAFFAFDPARTGI
VLCAGNKVSNEKRFYDEILPVADREYTNWLNILKEKE

Download         Length: 354 bp

>T214726 NZ_CP110198:3494216-3494434 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11156.89 Da        Isoelectric Point: 4.9507

>AT214726 WP_142446694.1 NZ_CP082360:2140493-2140795 [Klebsiella sp. CTHL.F3a]
MGRTLEQLIADEKPEVVAEAEAMAKDILLNIHLAELRERVQKTQVEMAQELGIKQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL

Download         Length: 303 bp

>AT214726 NZ_CP110198:3493814-3494188 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References