Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1651543..1652057 Replicon chromosome
Accession NZ_CP082359
Organism Limosilactobacillus fermentum strain ACA-DC 179

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6C1EMT8
Locus tag K7X51_RS08330 Protein ID WP_035437199.1
Coordinates 1651543..1651806 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C0WV67
Locus tag K7X51_RS08335 Protein ID WP_003684069.1
Coordinates 1651803..1652057 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7X51_RS08315 (K7X51_08315) 1647019..1647801 + 783 WP_021350113.1 arginine deiminase-related protein -
K7X51_RS08320 (K7X51_08320) 1648189..1649586 + 1398 WP_024271998.1 Na+/H+ antiporter NhaC family protein -
K7X51_RS08325 (K7X51_08325) 1650012..1651133 + 1122 WP_080662969.1 PTS sugar transporter subunit IIC -
K7X51_RS08330 (K7X51_08330) 1651543..1651806 - 264 WP_035437199.1 Txe/YoeB family addiction module toxin Toxin
K7X51_RS08335 (K7X51_08335) 1651803..1652057 - 255 WP_003684069.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K7X51_RS08340 (K7X51_08340) 1652443..1653813 - 1371 WP_003684065.1 FAD-dependent oxidoreductase -
K7X51_RS08345 (K7X51_08345) 1653942..1654259 - 318 Protein_1624 transposase -
K7X51_RS08350 (K7X51_08350) 1654319..1655506 - 1188 WP_014562705.1 IS256 family transposase -
K7X51_RS08355 (K7X51_08355) 1655621..1656496 - 876 Protein_1626 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-78)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-55)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10252.94 Da        Isoelectric Point: 10.3349

>T214722 WP_035437199.1 NZ_CP082359:c1651806-1651543 [Limosilactobacillus fermentum]
MSYAIKLKRSANKDLKKIKGSYLEKSFLQIIEQLRKDPLAPNQGFEKLVLPIKGFYSRRINIQHRLVYKVDQDTQTVIIY
SAWSHDE

Download         Length: 264 bp

>T214722 NZ_CP110198:881088-881486 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9745.04 Da        Isoelectric Point: 4.4237

>AT214722 WP_003684069.1 NZ_CP082359:c1652057-1651803 [Limosilactobacillus fermentum]
MDQIVTPTQARKDLFKIIKRINENNEPVVIKPTKADEKSVVVIGEDDWKAIQETLFLVNHGVDKQIKERENEPLDDFDDV
WGQL

Download         Length: 255 bp

>AT214722 NZ_CP110198:880861-881088 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C1EMT8

Antitoxin

Source ID Structure
AlphaFold DB A0A806T868

References