Detailed information of TA system TA214712

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-rdlD/SymE(toxin)
• Location: 4071880..4072289
• Replicon: chromosome
• Accession: NZ_CP082357
• Organism: Escherichia coli strain VCSW7

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A8S7AT09
• Locus tag: K7X31_RS19295
• Protein ID: WP_001600947.1
• Coordinates: 4071951..4072289 (+)
• Length: 113 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4071880..4071956 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7X31_RS19285 (4067068)	4067068..4068378	+	1311	WP_223024736.1	restriction endonuclease subunit S	-
K7X31_RS19290 (4068473)	4068473..4071736	+	3264	WP_223024737.1	HsdR family type I site-specific deoxyribonuclease	-
- (4071880)	4071880..4071956	-	77	NuclAT_10	-	Antitoxin
- (4071880)	4071880..4071956	-	77	NuclAT_10	-	Antitoxin
- (4071880)	4071880..4071956	-	77	NuclAT_10	-	Antitoxin
- (4071880)	4071880..4071956	-	77	NuclAT_10	-	Antitoxin
- (4071880)	4071880..4071956	-	77	NuclAT_11	-	Antitoxin
- (4071880)	4071880..4071956	-	77	NuclAT_11	-	Antitoxin
- (4071880)	4071880..4071956	-	77	NuclAT_11	-	Antitoxin
- (4071880)	4071880..4071956	-	77	NuclAT_11	-	Antitoxin
K7X31_RS19295 (4071951)	4071951..4072289	+	339	WP_001600947.1	endoribonuclease SymE	Toxin
K7X31_RS22945 (4072377)	4072377..4072424	-	48	WP_229017048.1	hypothetical protein	-
K7X31_RS19305 (4072672)	4072672..4074084	+	1413	WP_001600946.1	PLP-dependent aminotransferase family protein	-
K7X31_RS19310 (4074328)	4074328..4075284	-	957	WP_201482533.1	Rpn family recombination-promoting nuclease/putative transposase	-
K7X31_RS19315 (4075751)	4075751..4076983	+	1233	WP_137487613.1	multidrug efflux MFS transporter MdtM	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12348.09 Da
• Isoelectric Point: 7.8234

>T214712 WP_001600947.1 NZ_CP082357:4071951-4072289 [Escherichia coli]
MTDTHFIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFTTGTAVDVKVMEGCIVLTAQPAAAEESE
LMQSLRQVCKLSARKQRQVQDFIGVISSKTPR

Nucleotide

• Length: 339 bp

>T214712 NZ_CP110193:c5270021-5269638 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTACCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT214712 NZ_CP082357:c4071956-4071880 [Escherichia coli]
AGTCATAACTGCTATTCTCCTGGAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin