Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4024211..4024469 Replicon chromosome
Accession NZ_CP082355
Organism Escherichia coli strain VCSW5

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag K7X33_RS19175 Protein ID WP_000809168.1
Coordinates 4024317..4024469 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4024211..4024268 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7X33_RS19160 4020603..4021562 + 960 WP_000871681.1 hypothetical protein -
K7X33_RS19165 4021600..4022499 - 900 WP_001300855.1 transcriptional activator NhaR -
K7X33_RS19170 4022565..4023731 - 1167 WP_000681357.1 Na+/H+ antiporter NhaA -
- 4024211..4024268 - 58 - - Antitoxin
K7X33_RS19175 4024317..4024469 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
K7X33_RS19180 4024573..4025703 - 1131 WP_001118464.1 molecular chaperone DnaJ -
K7X33_RS19185 4025792..4027708 - 1917 WP_000516135.1 molecular chaperone DnaK -
K7X33_RS19190 4028084..4028488 + 405 WP_000843583.1 DUF2541 family protein -
K7X33_RS19195 4028514..4029227 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T214686 WP_000809168.1 NZ_CP082355:4024317-4024469 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T214686 NZ_CP110189:c1031131-1030850 [Vibrio cholerae]
ATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTTTTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTC
ACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCTGTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTA
CGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCTTGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATT
CTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCTAA

Antitoxin


Download         Length: 58 bp

>AT214686 NZ_CP082355:c4024268-4024211 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References