Detailed information of TA system TA021466

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1929117..1929299
• Replicon: chromosome
• Accession: NC_007793
• Organism: Staphylococcus aureus subsp. aureus USA300 FPR3757

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: SAUSA300_RS15795
• Protein ID: WP_001801861.1
• Coordinates: 1929117..1929212 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1929240..1929299 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAUSA300_RS09520	1924777..1925403	+	627	Protein_1841	hypothetical protein	-
SAUSA300_RS09525	1925444..1925788	+	345	WP_000627551.1	DUF3969 family protein	-
SAUSA300_RS09530	1925886..1926437	+	552	WP_000414205.1	hypothetical protein	-
SAUSA300_RS09535	1926655..1927296	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
SAUSA300_RS09540	1927410..1927595	-	186	WP_000809857.1	hypothetical protein	-
SAUSA300_RS09545	1927597..1927773	-	177	WP_000375476.1	hypothetical protein	-
SAUSA300_RS09550	1927784..1928167	-	384	WP_000070811.1	hypothetical protein	-
SAUSA300_RS09560	1928771..1928914	-	144	WP_001549059.1	transposase	-
SAUSA300_RS15795	1929117..1929212	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1929240..1929299	-	60	-	-	Antitoxin
SAUSA300_RS09565	1929335..1929436	+	102	WP_001791893.1	hypothetical protein	-
SAUSA300_RS15405	1929414..1929590	-	177	Protein_1851	transposase	-
SAUSA300_RS09570	1929784..1930161	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1922217..1947819	25602

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T21466 WP_001801861.1 NC_007793:1929117-1929212 [Staphylococcus aureus subsp. aureus USA300_FPR3757]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T21466 NC_007793:1929117-1929212 [Staphylococcus aureus subsp. aureus USA300_FPR3757]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT21466 NC_007793:c1929299-1929240 [Staphylococcus aureus subsp. aureus USA300_FPR3757]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin