Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 266020..266671 Replicon plasmid unnamed
Accession NZ_CP082347
Organism Pantoea dispersa strain Lsch

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K7H94_RS19925 Protein ID WP_141496026.1
Coordinates 266020..266364 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8E1S3S0
Locus tag K7H94_RS19930 Protein ID WP_058758775.1
Coordinates 266357..266671 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H94_RS19920 (K7H94_19920) 262546..265917 + 3372 WP_222952340.1 autotransporter outer membrane beta-barrel domain-containing protein -
K7H94_RS19925 (K7H94_19925) 266020..266364 + 345 WP_141496026.1 toxin Toxin
K7H94_RS19930 (K7H94_19930) 266357..266671 + 315 WP_058758775.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
K7H94_RS19935 (K7H94_19935) 266799..267224 + 426 WP_222952341.1 DCC1-like thiol-disulfide oxidoreductase family protein -
K7H94_RS19940 (K7H94_19940) 267221..267649 - 429 WP_059012276.1 arsenate reductase (glutaredoxin) -
K7H94_RS19945 (K7H94_19945) 267667..268950 - 1284 WP_222952342.1 arsenic transporter -
K7H94_RS19950 (K7H94_19950) 269020..269373 - 354 WP_021509466.1 metalloregulator ArsR/SmtB family transcription factor -
K7H94_RS19955 (K7H94_19955) 269722..271017 + 1296 WP_222952343.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..689940 689940


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(43-88)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13451.21 Da        Isoelectric Point: 9.6738

>T214629 WP_141496026.1 NZ_CP082347:266020-266364 [Pantoea dispersa]
MQATFIELSSFQKYRADYLSDDQFRLFQNMLLADPEKGDVIPDTGGLRKVRFRDERRNKGSRGGIRVIYYWTNEKGQFIL
FSIYDKDQRDDLTKQQRDALAEALNVIKKGLRHD

Download         Length: 345 bp

>T214629 NZ_CP110153:c4910558-4910274 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11984.71 Da        Isoelectric Point: 8.5238

>AT214629 WP_058758775.1 NZ_CP082347:266357-266671 [Pantoea dispersa]
MTERDIFSELMAGMQELKDHQDGKITLKTYKVSKRAPVTIAPQELRDVREKLNLSQAVFAHYLHTGETTYQNWEQGRAKP
NAQAVLLIRMVQQNPETLQTLAQF

Download         Length: 315 bp

>AT214629 NZ_CP110153:c4910790-4910548 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References