Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 532831..533485 Replicon plasmid unnamed
Accession NZ_CP082342
Organism Pantoea dispersa strain AHKW2b

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K7X52_RS22280 Protein ID WP_058770321.1
Coordinates 532831..533202 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K7X52_RS22285 Protein ID WP_222986846.1
Coordinates 533186..533485 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7X52_RS22260 (K7X52_22260) 528114..529493 + 1380 WP_166719412.1 heavy metal sensor histidine kinase -
K7X52_RS22265 (K7X52_22265) 529523..530176 - 654 WP_222986843.1 oxygen-insensitive NAD(P)H nitroreductase -
K7X52_RS22270 (K7X52_22270) 530281..531282 - 1002 WP_021508931.1 zinc-binding alcohol dehydrogenase family protein -
K7X52_RS22275 (K7X52_22275) 531419..532336 + 918 WP_222986845.1 LysR family transcriptional regulator -
K7X52_RS22280 (K7X52_22280) 532831..533202 + 372 WP_058770321.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K7X52_RS22285 (K7X52_22285) 533186..533485 + 300 WP_222986846.1 XRE family transcriptional regulator Antitoxin
K7X52_RS22290 (K7X52_22290) 533563..534030 - 468 WP_058759022.1 hypothetical protein -
K7X52_RS22295 (K7X52_22295) 534216..535145 - 930 WP_222986848.1 ABC transporter substrate-binding protein -
K7X52_RS22300 (K7X52_22300) 535155..535889 - 735 WP_222986850.1 ABC transporter permease -
K7X52_RS22305 (K7X52_22305) 535873..536589 - 717 WP_222986852.1 ABC transporter ATP-binding protein -
K7X52_RS22310 (K7X52_22310) 536586..537554 - 969 WP_222987171.1 HesA/MoeB/ThiF family protein -
K7X52_RS22315 (K7X52_22315) 537565..538323 - 759 WP_150360082.1 thiazole synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..653898 653898


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-88)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14357.53 Da        Isoelectric Point: 10.3096

>T214618 WP_058770321.1 NZ_CP082342:532831-533202 [Pantoea dispersa]
VWQVEATDRFWKWLQAQDEALRLDVLAALKLLAQDGPHLGRPFVDTLMLSRVPNMKELRVQSKGRPIRSFFVFDPRRHAI
VLCAGNKQGKNQKRFYQQMLRIAETEYHHHLNAIGETHNENLG

Download         Length: 372 bp

>T214618 NZ_CP110151:19204-19674 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATAGCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11264.02 Da        Isoelectric Point: 7.3174

>AT214618 WP_222986846.1 NZ_CP082342:533186-533485 [Pantoea dispersa]
MKTLDEMLAALTPEQQHQVNERVSQMRLEYQLYQLREQMQRTQRQQAQAMHIAQSSVAAMEARGAELKISTLKRYIEALG
GELTLGVKMPGGQHVDLII

Download         Length: 300 bp

>AT214618 NZ_CP110151:18764-19207 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATAAATGAAGGTCTGGACGGGAAGGTGGCGAACCGGATAACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References