Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 532831..533485 | Replicon | plasmid unnamed |
| Accession | NZ_CP082342 | ||
| Organism | Pantoea dispersa strain AHKW2b | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | K7X52_RS22280 | Protein ID | WP_058770321.1 |
| Coordinates | 532831..533202 (+) | Length | 124 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | K7X52_RS22285 | Protein ID | WP_222986846.1 |
| Coordinates | 533186..533485 (+) | Length | 100 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K7X52_RS22260 (K7X52_22260) | 528114..529493 | + | 1380 | WP_166719412.1 | heavy metal sensor histidine kinase | - |
| K7X52_RS22265 (K7X52_22265) | 529523..530176 | - | 654 | WP_222986843.1 | oxygen-insensitive NAD(P)H nitroreductase | - |
| K7X52_RS22270 (K7X52_22270) | 530281..531282 | - | 1002 | WP_021508931.1 | zinc-binding alcohol dehydrogenase family protein | - |
| K7X52_RS22275 (K7X52_22275) | 531419..532336 | + | 918 | WP_222986845.1 | LysR family transcriptional regulator | - |
| K7X52_RS22280 (K7X52_22280) | 532831..533202 | + | 372 | WP_058770321.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K7X52_RS22285 (K7X52_22285) | 533186..533485 | + | 300 | WP_222986846.1 | XRE family transcriptional regulator | Antitoxin |
| K7X52_RS22290 (K7X52_22290) | 533563..534030 | - | 468 | WP_058759022.1 | hypothetical protein | - |
| K7X52_RS22295 (K7X52_22295) | 534216..535145 | - | 930 | WP_222986848.1 | ABC transporter substrate-binding protein | - |
| K7X52_RS22300 (K7X52_22300) | 535155..535889 | - | 735 | WP_222986850.1 | ABC transporter permease | - |
| K7X52_RS22305 (K7X52_22305) | 535873..536589 | - | 717 | WP_222986852.1 | ABC transporter ATP-binding protein | - |
| K7X52_RS22310 (K7X52_22310) | 536586..537554 | - | 969 | WP_222987171.1 | HesA/MoeB/ThiF family protein | - |
| K7X52_RS22315 (K7X52_22315) | 537565..538323 | - | 759 | WP_150360082.1 | thiazole synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | iroN | 1..653898 | 653898 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 124 a.a. Molecular weight: 14357.53 Da Isoelectric Point: 10.3096
>T214618 WP_058770321.1 NZ_CP082342:532831-533202 [Pantoea dispersa]
VWQVEATDRFWKWLQAQDEALRLDVLAALKLLAQDGPHLGRPFVDTLMLSRVPNMKELRVQSKGRPIRSFFVFDPRRHAI
VLCAGNKQGKNQKRFYQQMLRIAETEYHHHLNAIGETHNENLG
VWQVEATDRFWKWLQAQDEALRLDVLAALKLLAQDGPHLGRPFVDTLMLSRVPNMKELRVQSKGRPIRSFFVFDPRRHAI
VLCAGNKQGKNQKRFYQQMLRIAETEYHHHLNAIGETHNENLG
Download Length: 372 bp
>T214618 NZ_CP110151:19204-19674 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATAGCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATAGCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
Antitoxin
Download Length: 100 a.a. Molecular weight: 11264.02 Da Isoelectric Point: 7.3174
>AT214618 WP_222986846.1 NZ_CP082342:533186-533485 [Pantoea dispersa]
MKTLDEMLAALTPEQQHQVNERVSQMRLEYQLYQLREQMQRTQRQQAQAMHIAQSSVAAMEARGAELKISTLKRYIEALG
GELTLGVKMPGGQHVDLII
MKTLDEMLAALTPEQQHQVNERVSQMRLEYQLYQLREQMQRTQRQQAQAMHIAQSSVAAMEARGAELKISTLKRYIEALG
GELTLGVKMPGGQHVDLII
Download Length: 300 bp
>AT214618 NZ_CP110151:18764-19207 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATAAATGAAGGTCTGGACGGGAAGGTGGCGAACCGGATAACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATAAATGAAGGTCTGGACGGGAAGGTGGCGAACCGGATAACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|