Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 242610..243261 Replicon plasmid unnamed
Accession NZ_CP082342
Organism Pantoea dispersa strain AHKW2b

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K7X52_RS20980 Protein ID WP_222987107.1
Coordinates 242610..242954 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8E1S3S0
Locus tag K7X52_RS20985 Protein ID WP_058758775.1
Coordinates 242947..243261 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7X52_RS20975 (K7X52_20975) 238982..242506 + 3525 WP_222987106.1 autotransporter outer membrane beta-barrel domain-containing protein -
K7X52_RS20980 (K7X52_20980) 242610..242954 + 345 WP_222987107.1 toxin Toxin
K7X52_RS20985 (K7X52_20985) 242947..243261 + 315 WP_058758775.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
K7X52_RS20990 (K7X52_20990) 243390..243815 + 426 WP_021509469.1 thiol-disulfide oxidoreductase DCC family protein -
K7X52_RS20995 (K7X52_20995) 243812..244240 - 429 WP_222987108.1 arsenate reductase (glutaredoxin) -
K7X52_RS21000 (K7X52_21000) 244258..245541 - 1284 WP_222987109.1 arsenic transporter -
K7X52_RS21005 (K7X52_21005) 245611..245964 - 354 WP_021509466.1 metalloregulator ArsR/SmtB family transcription factor -
K7X52_RS21010 (K7X52_21010) 246313..247608 + 1296 WP_021509465.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..653898 653898


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(43-88)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13478.28 Da        Isoelectric Point: 9.9069

>T214616 WP_222987107.1 NZ_CP082342:242610-242954 [Pantoea dispersa]
MQATFIELSSFQKYRADYLSDDQFRLFQNMLLADPEKGDIIPDTGGLRKVRFRDERRNKGSRGGIRIIYYWTNEKGQFIL
FSIYNKDQRDDLTKQQRDALAEALNVIKKGLRHD

Download         Length: 345 bp

>T214616 NZ_CP110150:c4801498-4800581 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11984.71 Da        Isoelectric Point: 8.5238

>AT214616 WP_058758775.1 NZ_CP082342:242947-243261 [Pantoea dispersa]
MTERDIFSELMAGMQELKDHQDGKITLKTYKVSKRAPVTIAPQELRDVREKLNLSQAVFAHYLHTGETTYQNWEQGRAKP
NAQAVLLIRMVQQNPETLQTLAQF

Download         Length: 315 bp

>AT214616 NZ_CP110150:c4802262-4801504 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTTGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References