Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3716822..3717407 Replicon chromosome
Accession NZ_CP082341
Organism Pantoea dispersa strain AHKW2b

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K7X52_RS24945 Protein ID WP_262417938.1
Coordinates 3717108..3717407 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K7X52_RS17590 Protein ID WP_222985865.1
Coordinates 3716822..3717121 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7X52_RS17570 (K7X52_17570) 3712823..3714124 + 1302 WP_222985863.1 anaerobic C4-dicarboxylate transporter -
K7X52_RS17575 (K7X52_17575) 3714211..3715908 + 1698 WP_222985864.1 protein-disulfide reductase DsbD -
K7X52_RS17580 (K7X52_17580) 3715975..3716553 + 579 WP_021507771.1 transcriptional regulator -
K7X52_RS17590 (K7X52_17590) 3716822..3717121 - 300 WP_222985865.1 helix-turn-helix transcriptional regulator Antitoxin
K7X52_RS24945 3717108..3717407 - 300 WP_262417938.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K7X52_RS17600 (K7X52_17600) 3717879..3718127 + 249 Protein_3437 LysR family transcriptional regulator -
K7X52_RS17605 (K7X52_17605) 3718228..3719397 - 1170 WP_215786693.1 Gfo/Idh/MocA family oxidoreductase -
K7X52_RS17610 (K7X52_17610) 3719408..3720331 - 924 WP_222985867.1 TIM barrel protein -
K7X52_RS17615 (K7X52_17615) 3720530..3721549 - 1020 WP_222985868.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(4-87)

Antitoxin

HigA2-like, helix-turn-helix domain

(16-88)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11249.97 Da        Isoelectric Point: 10.5415

>T214612 WP_262417938.1 NZ_CP082341:c3717407-3717108 [Pantoea dispersa]
MIEDVLASLAVLRAFGPTLGRPDVDTLVGSRFSNMKELRVQSNGRAIRAFFAFDPVRRAIVLCAGNKTGTHQRRFYQAMI
KLADREYQQHLEEMNHAKT

Download         Length: 300 bp

>T214612 NZ_CP110150:3908826-3909044 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10878.72 Da        Isoelectric Point: 8.5775

>AT214612 WP_222985865.1 NZ_CP082341:c3717121-3716822 [Pantoea dispersa]
MPKLEDLIAQRSPESQARIINKAAEKILEIRLRQLREELALSQVQLAEKMGVSQPAIAAIEARGDELKLSSLKKYVEALG
GKLSVTVELPAGDGRIFQL

Download         Length: 300 bp

>AT214612 NZ_CP110150:3908425-3908799 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References