Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1416..2149 Replicon plasmid unnamed
Accession NZ_CP082309
Organism Vibrio alginolyticus strain HNV2

Toxin (Protein)


Gene name higB Uniprot ID A0A0N8HLP5
Locus tag K6748_RS23370 Protein ID WP_054579163.1
Coordinates 1416..1733 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0P7ER46
Locus tag K6748_RS23375 Protein ID WP_025998577.1
Coordinates 1736..2149 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6748_RS23355 (K6748_23245) 534..830 + 297 WP_238959172.1 DUF6283 family protein -
K6748_RS23360 (K6748_23250) 808..984 + 177 WP_238959173.1 hypothetical protein -
K6748_RS23365 (K6748_23255) 1110..1292 + 183 WP_238959174.1 hypothetical protein -
K6748_RS23370 (K6748_23260) 1416..1733 + 318 WP_054579163.1 type II toxin-antitoxin system HigB family toxin Toxin
K6748_RS23375 (K6748_23265) 1736..2149 + 414 WP_025998577.1 hypothetical protein Antitoxin
K6748_RS23380 (K6748_23270) 2455..3186 + 732 WP_238959175.1 DUF2971 domain-containing protein -
K6748_RS23385 3341..3874 + 534 WP_238959176.1 hypothetical protein -
K6748_RS23390 (K6748_23280) 4477..5007 + 531 WP_215810665.1 GNAT family protein -
K6748_RS23395 (K6748_23285) 5136..5543 + 408 WP_025527517.1 OsmC family protein -
K6748_RS23400 (K6748_23290) 5707..6375 + 669 WP_213986513.1 hypothetical protein -
K6748_RS23405 (K6748_23295) 6390..6482 + 93 WP_213986512.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..90854 90854


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-94)

Antitoxin

Antitoxin HigA

(8-137)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12090.05 Da        Isoelectric Point: 10.0563

>T214541 WP_054579163.1 NZ_CP082309:1416-1733 [Vibrio alginolyticus]
MHVIKREPFETAKRLYPQCAEALDSTFKTLKATKAKTPEQLKQLFPSLDNFKYVDKWYVIDIGGGSLRLIAFIEFTGGKC
FVKHIVTHAEYDKITDQHRTKGKRG

Download         Length: 318 bp

>T214541 NZ_CP110130:c5411333-5411058 [Methylorubrum extorquens]
ATGTTGATTGTCTGGGACGAGCCCAAGCGCCTGACCAACCTGCAAAAGCACGGTCTCGACTTCGCGGACTTCGAGGCGGG
GTTCGACTTCGAGACCGCTCTTGTCGCGGTTGCCCAACCGAGCGCCGCTGGCTCAGCCCGAATGAAGATCATCGGCGAGT
TCGACGGACAGACGGTGGTGGCAGCGATCATCGCTCCCTTGGGACGGGAAGCGATCTCGCTCATCAGCCTGCGCCGAGCC
AGCCGGAGCGAACGGAGGCTCTACGATGCCCGCTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15845.18 Da        Isoelectric Point: 4.5932

>AT214541 WP_025998577.1 NZ_CP082309:1736-2149 [Vibrio alginolyticus]
MNIQALKTLSNEIHTAMPWLQGIRDHEQYLELMELMDTLVEDYEENHVLIDLLFPVLERYEEESEHFQEFNAHIDSLDTG
IATLRVLIDQYRLTLSDLPEIGGKSLVSLILSGKRQLTVGHIKALSERFGVPKHMFI

Download         Length: 414 bp

>AT214541 NZ_CP110130:c5411068-5410751 [Methylorubrum extorquens]
ATGCCCGCTGACAAGCCCGATCGGAGACCGACCACGACCTCGGAGGAGGCCGGGATCCAAGCCGGCATCGCGGCCGATCC
CGACAATCCGGAATGGACCGAAGCGGACTTTCGAAGCGCCGTGCCCTTCGAACAGGCCTTTCCCGTCCTCGCAGAGAAAC
TGCGCCGCACCCGCGGCCCCCAAAGCGCTCCGACCAAACAGCTCGTCAGCTTGAGGCTCGATCAGGACGTCCTGCTTCGT
TTCAGGGCGACCGGTCCGGGCTGGCAGTCTCGGATGAACGAAGCCCTGCGCCGGGCCGCGGCCGATCTTCCCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N8HLP5

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7ER46

References