Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 86061..86779 Replicon plasmid p3_CQ10
Accession NZ_CP082295
Organism Pantoea agglomerans strain CQ10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K6R05_RS20635 Protein ID WP_161736330.1
Coordinates 86061..86372 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6R05_RS20640 Protein ID WP_161736331.1
Coordinates 86369..86779 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6R05_RS20620 (K6R05_20620) 81321..82460 + 1140 WP_262390937.1 site-specific integrase -
K6R05_RS20625 (K6R05_20625) 82478..83020 - 543 WP_262390941.1 lipid IV(A) palmitoyltransferase PagP -
K6R05_RS20630 (K6R05_20630) 83494..85716 + 2223 WP_222925725.1 ferric-rhodotorulic acid/ferric-coprogen receptor FhuE -
K6R05_RS20635 (K6R05_20635) 86061..86372 + 312 WP_161736330.1 type II toxin-antitoxin system HigB family toxin Toxin
K6R05_RS20640 (K6R05_20640) 86369..86779 + 411 WP_161736331.1 helix-turn-helix domain-containing protein Antitoxin
K6R05_RS20645 (K6R05_20645) 86893..87738 - 846 WP_161736332.1 VOC family protein -
K6R05_RS20650 (K6R05_20650) 87759..88898 - 1140 WP_222925726.1 amidohydrolase -
K6R05_RS20655 (K6R05_20655) 88901..90001 - 1101 WP_222925727.1 alkylhydroperoxidase domain protein -
K6R05_RS20660 (K6R05_20660) 89998..91005 - 1008 WP_222925728.1 putative FMN-dependent luciferase-like monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..143561 143561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Antitoxin HigA

(5-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12122.98 Da        Isoelectric Point: 9.0170

>T214535 WP_161736330.1 NZ_CP082295:86061-86372 [Pantoea agglomerans]
MHVISCVPFDEAARKHPNAAAALDLLYRHLRQGDFSGPDDLRALYASLDRMKYRAKWWVIDVSGNHLRVIFFADFERSKI
FIKHICTHAEYDKLVKKYREVTE

Download         Length: 312 bp

>T214535 NZ_CP110130:1011281-1011571 [Methylorubrum extorquens]
ATGAGCGTCCGCCTCTCGCCGAGGGCGCGCGGGGATCTCAGCCGGATCTGGGACGATTCGGCCGAGCGCTGGGGAGCGGA
TCAGGCCGACCGCTACATCCGCCTTCGGGCTGGAGGCTTCGACCGATTGGCGGAGGATCCGGCTCGGGGTCTAAGGGCCG
ATGAGATCCGCAAGGGGTATTTCCGCCTCTCCGTCGGATCGCACGTCCTATTCTACCGCCTGGGCGCCGAGGGCGGCATC
GAGGTCATCCGCATCCTTCACGGGCGGATGGATTTCAAACGCCATCTTTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15285.25 Da        Isoelectric Point: 4.7755

>AT214535 WP_161736331.1 NZ_CP082295:86369-86779 [Pantoea agglomerans]
MNTEAIRLSNQLAEAVPLLAGSNQRHDYQEALELVEYLIEHEPDNPLVDLLCARIAHYEDNDPAMADFNSRQREISTGPG
VLRVLIEQHNLSLSDFENEIGKKSLVSRILSGDRQLTVSHIRALCARFGLSPSLFF

Download         Length: 411 bp

>AT214535 NZ_CP110130:1011036-1011284 [Methylorubrum extorquens]
ATGTCGCGAAACACGTCCGTCTCGCTCGGCGAGCACTTTGCGCAGTTCATCGACCGCCAGGTCGAGGGGGGACGTTACGG
CTCCGCCAGCGAAGTCGTCCGTGCCGGACTTCGTCTTCTGGAGGAGCAGGAAGCCGCCCTCAACACGCTCCGGGCCGCGC
TGATCGAGGGGGAGGAAAGCGGCTCGCCCGAGCCCTTCGATACGGAGACCTTTCTCCGGGAGAAGCGTGAGGGCGCGATC
CGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References