Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3669979..3670624 Replicon chromosome
Accession NZ_CP082292
Organism Pantoea agglomerans strain CQ10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K6R05_RS17165 Protein ID WP_022625232.1
Coordinates 3670271..3670624 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6R05_RS17160 Protein ID WP_161733580.1
Coordinates 3669979..3670278 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6R05_RS17145 (K6R05_17145) 3665893..3667677 - 1785 WP_161733586.1 GMC family oxidoreductase -
K6R05_RS17150 (K6R05_17150) 3667680..3668414 - 735 WP_161733584.1 gluconate 2-dehydrogenase subunit 3 family protein -
K6R05_RS17155 (K6R05_17155) 3668690..3669931 + 1242 WP_161733582.1 peptide antibiotic transporter SbmA -
K6R05_RS17160 (K6R05_17160) 3669979..3670278 - 300 WP_161733580.1 helix-turn-helix transcriptional regulator Antitoxin
K6R05_RS17165 (K6R05_17165) 3670271..3670624 - 354 WP_022625232.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6R05_RS17170 (K6R05_17170) 3670835..3671887 - 1053 WP_161733578.1 YncE family protein -
K6R05_RS17175 (K6R05_17175) 3672085..3672294 - 210 WP_009092571.1 DUF1471 domain-containing protein -
K6R05_RS17180 (K6R05_17180) 3672507..3673694 - 1188 WP_161733576.1 MFS transporter -
K6R05_RS17185 (K6R05_17185) 3673799..3674764 + 966 WP_161733574.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13407.28 Da        Isoelectric Point: 6.4741

>T214532 WP_022625232.1 NZ_CP082292:c3670624-3670271 [Pantoea agglomerans]
MWDVDTTKRFDEWFKAQSEELKEDMLAAIVILSEYGPHLARPFADTVDGSDFPNMKELRVQHQGKPIRAFFAFDPSRRGI
VLCAGDKTGVKEKKFYKDMIKLADAEFRKYLNGGDNG

Download         Length: 354 bp

>T214532 NZ_CP110128:5112828-5113136 [Pseudomonas sp. WJP1]
ATGAGCCAGACTTTGACGACTTTCGATATGGCGGCTCTGCTCGACAGCGACGAGGCCATCAGCGAGTACCTATCCCAGGT
GCTGGCAGACGGTGACAATGAGGAGTTTCTTCGTGCCGTCGGGTACGTTGTAAAAGCCCGCGGCATGACACAGGTAGCAA
AAAATTCCGGAATGGGTCGCGAAAGCTTGTACAAGGCCTTCGCTCCTGGCGCAAAACCACGTTTCAATACAGTTTTGAAA
GTGATTCACGCACTGGGTATCGATCTATGTGCGCAACCGGGTCATGTCATCAATCACTCAAACTCTTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11094.92 Da        Isoelectric Point: 9.8101

>AT214532 WP_161733580.1 NZ_CP082292:c3670278-3669979 [Pantoea agglomerans]
MANLKELMANQSPESRERIAKKVDAMRQAIALHMLREELNLSQTEMAQAMGVKQPTIARMEQADNDPRLSTLKRYVTALG
GEISIDVKLPTGKRIAFDL

Download         Length: 300 bp

>AT214532 NZ_CP110128:5112532-5112825 [Pseudomonas sp. WJP1]
ATGAATTATCTTGTCCAGCAAACAGCGATTTTCTCCGCATGGCACACCTCCATCCGTGATTTGCGGGCCAGGATTGCCAT
TGCTCGTCGCATTGAACGCGCTTGCGCGGGAAATTTGGGCGATATCAAACCAGTAGGTGATGGCGTTTCCGAAATGCGCG
TGGATGTAGGTGCCGGATACCGGATTTACTTCACGATGCGCAAGACTGTCGTCATCGTCTTGCTTGCAGGGGGCGACAAG
TCATCACAAAACGCTGATATCAAACGTGCAAAAAAATTGGCAAAGGAGGTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References