Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 352361..353007 | Replicon | chromosome |
Accession | NZ_CP082290 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain Kp6 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A332YAY3 |
Locus tag | K6T93_RS01625 | Protein ID | WP_032435150.1 |
Coordinates | 352361..352708 (+) | Length | 116 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A231WWU8 |
Locus tag | K6T93_RS01630 | Protein ID | WP_004174017.1 |
Coordinates | 352708..353007 (+) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K6T93_RS01615 (K6T93_01615) | 348287..349720 | + | 1434 | WP_002920564.1 | glycogen synthase GlgA | - |
K6T93_RS01620 (K6T93_01620) | 349738..352185 | + | 2448 | WP_002920561.1 | glycogen phosphorylase | - |
K6T93_RS01625 (K6T93_01625) | 352361..352708 | + | 348 | WP_032435150.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
K6T93_RS01630 (K6T93_01630) | 352708..353007 | + | 300 | WP_004174017.1 | XRE family transcriptional regulator | Antitoxin |
K6T93_RS01635 (K6T93_01635) | 353070..354578 | - | 1509 | WP_002920554.1 | glycerol-3-phosphate dehydrogenase | - |
K6T93_RS01640 (K6T93_01640) | 354783..355112 | + | 330 | WP_002920552.1 | thiosulfate sulfurtransferase GlpE | - |
K6T93_RS01645 (K6T93_01645) | 355163..355993 | + | 831 | WP_004151408.1 | rhomboid family intramembrane serine protease GlpG | - |
K6T93_RS01650 (K6T93_01650) | 356043..356801 | + | 759 | WP_002920548.1 | DeoR/GlpR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 13531.52 Da Isoelectric Point: 5.6749
>T214510 WP_032435150.1 NZ_CP082290:352361-352708 [Klebsiella pneumoniae subsp. pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER
Download Length: 348 bp
>T214510 NZ_CP110118:c65760-65611 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 10844.64 Da Isoelectric Point: 10.1464
>AT214510 WP_004174017.1 NZ_CP082290:352708-353007 [Klebsiella pneumoniae subsp. pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL
Download Length: 300 bp
>AT214510 NZ_CP110118:65804-65865 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A332YAY3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A231WWU8 |