Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 352361..353007 Replicon chromosome
Accession NZ_CP082290
Organism Klebsiella pneumoniae subsp. pneumoniae strain Kp6

Toxin (Protein)


Gene name higB Uniprot ID A0A332YAY3
Locus tag K6T93_RS01625 Protein ID WP_032435150.1
Coordinates 352361..352708 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag K6T93_RS01630 Protein ID WP_004174017.1
Coordinates 352708..353007 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6T93_RS01615 (K6T93_01615) 348287..349720 + 1434 WP_002920564.1 glycogen synthase GlgA -
K6T93_RS01620 (K6T93_01620) 349738..352185 + 2448 WP_002920561.1 glycogen phosphorylase -
K6T93_RS01625 (K6T93_01625) 352361..352708 + 348 WP_032435150.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6T93_RS01630 (K6T93_01630) 352708..353007 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
K6T93_RS01635 (K6T93_01635) 353070..354578 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
K6T93_RS01640 (K6T93_01640) 354783..355112 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
K6T93_RS01645 (K6T93_01645) 355163..355993 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
K6T93_RS01650 (K6T93_01650) 356043..356801 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13531.52 Da        Isoelectric Point: 5.6749

>T214510 WP_032435150.1 NZ_CP082290:352361-352708 [Klebsiella pneumoniae subsp. pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T214510 NZ_CP110118:c65760-65611 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT214510 WP_004174017.1 NZ_CP082290:352708-353007 [Klebsiella pneumoniae subsp. pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT214510 NZ_CP110118:65804-65865 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332YAY3

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References