Detailed information of TA system TA214466

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2260499..2260742
• Replicon: chromosome
• Accession: NZ_CP082269
• Organism: Enterobacter sp. C2

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: A0A090VSD6
• Locus tag: K4042_RS11050
• Protein ID: WP_072015212.1
• Coordinates: 2260590..2260742 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	2260499..2260546 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K4042_RS11040	2255613..2259515	-	3903	WP_222887813.1	ATP-dependent RNA helicase HrpA	-
K4042_RS11045	2259718..2260323	+	606	WP_144815390.1	FMN-dependent NADH-azoreductase	-
-	2260499..2260546	-	48	-	-	Antitoxin
K4042_RS11050	2260590..2260742	+	153	WP_072015212.1	Hok/Gef family protein	Toxin
K4042_RS11055	2260804..2260986	-	183	WP_222887815.1	YnbE family lipoprotein	-
K4042_RS11060	2260983..2263619	-	2637	WP_222887817.1	YdbH family protein	-
K4042_RS11065	2263709..2264359	-	651	WP_222887819.1	metal-binding protein ZinT	-
K4042_RS11070	2264483..2265472	+	990	WP_222887821.1	2-hydroxyacid dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5544.73 Da
• Isoelectric Point: 9.7882

>T214466 WP_072015212.1 NZ_CP082269:2260590-2260742 [Enterobacter sp. C2]
MPTKYALVAIIVLCGTALGFTLMVRGSLCELSFKQRSMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T214466 NZ_CP110087:c2258051-2257659 [Moraxella bovis]
ATGAAATATTTGCTGGACACCAATGCAGTCATTGCGATTTTGAATGCCAGTGAACGATTTTTGACCACGCTAGAACGGCA
TAAAGAGCGTGAAATTGCCATCTCGTCAATTGTTTTGTCGGAGCTGTATTATGGGGCGTACAAAAGCCAAAAAACCGCCC
AAAACCTTGAAAAAATCAATCTACTACCCTTTGAAGTGTTGCAATTTAATTCACAGGACGCTGATAAGGCTGGCGAAATT
GGTGCAACCCTAGAAAGGCGTGGCACACCCATTGGTTCTTATGACACGCTGATTGCAGGGCAAGCGATTGCCAATGATTT
GATTGTTATTACTGACAATGTGCGAGAATTTCTCCGAGTGGACGGTTTGCAAATTGAAAATTGGTTAAAATAA

Antitoxin

Nucleotide

• Length: 48 bp

>AT214466 NZ_CP082269:c2260546-2260499 [Enterobacter sp. C2]
GGGTTTGGTCGTTAGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTT

Structures

Toxin

• AlphaFold DB: A0A090VSD6

Antitoxin