Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1293564..1294161 Replicon chromosome
Accession NZ_CP082238
Organism Acidithiobacillus ferrooxidans strain BYM

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag K7B00_RS06650 Protein ID WP_054608787.1
Coordinates 1293564..1293842 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K7B00_RS06655 Protein ID WP_054608786.1
Coordinates 1293859..1294161 (+) Length 101 a.a.

Genomic Context

K7B00_RS06650K7B00_RS06655K7B00_RS06670K7B00_RS06675K7B00_RS06680K7B00_RS06630K7B00_RS06635K7B00_RS06640K7B00_RS06645K7B00_RS06660K7B00_RS06665K7B00_RS06685
Location: 1293564..1293842 (279 bp)
Type: Toxin
Protein ID: WP_054608787.1
Location: 1293859..1294161 (303 bp)
Type: Antitoxin
Protein ID: WP_054608786.1
Location: 1296611..1296883 (273 bp)
Type: Others
Protein ID: WP_054608783.1
Location: 1296910..1297176 (267 bp)
Type: Others
Protein ID: WP_054608782.1
Location: 1297247..1297669 (423 bp)
Type: Others
Protein ID: WP_054608781.1
Location: 1288642..1290717 (2076 bp)
Type: Others
Protein ID: WP_157293188.1
Location: 1290698..1290877 (180 bp)
Type: Others
Protein ID: WP_146235814.1
Location: 1291017..1291952 (936 bp)
Type: Others
Protein ID: WP_070807680.1
Location: 1291956..1293407 (1452 bp)
Type: Others
Protein ID: WP_054608788.1
Location: 1294180..1296117 (1938 bp)
Type: Others
Protein ID: WP_054608785.1
Location: 1296117..1296443 (327 bp)
Type: Others
Protein ID: WP_054608784.1
Location: 1297788..1298948 (1161 bp)
Type: Others
Protein ID: WP_229129786.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K7B00_RS06630 (K7B00_06630)1288642..1290717-2076WP_157293188.1zincin-like metallopeptidase domain-containing protein-
K7B00_RS06635 (K7B00_06635)1290698..1290877-180WP_146235814.1hypothetical protein-
K7B00_RS06640 (K7B00_06640)1291017..1291952-936WP_070807680.1DNA adenine methylase-
K7B00_RS06645 (K7B00_06645)1291956..1293407-1452WP_054608788.1toprim domain-containing protein-
K7B00_RS06650 (K7B00_06650)1293564..1293842+279WP_054608787.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K7B00_RS06655 (K7B00_06655)1293859..1294161+303WP_054608786.1HigA family addiction module antitoxinAntitoxin
K7B00_RS06660 (K7B00_06660)1294180..1296117-1938WP_054608785.1relaxase/mobilization nuclease domain-containing protein-
K7B00_RS06665 (K7B00_06665)1296117..1296443-327WP_054608784.1hypothetical protein-
K7B00_RS06670 (K7B00_06670)1296611..1296883+273WP_054608783.1HU family DNA-binding protein-
K7B00_RS06675 (K7B00_06675)1296910..1297176+267WP_054608782.1superinfection immunity protein-
K7B00_RS06680 (K7B00_06680)1297247..1297669+423WP_054608781.1hypothetical protein-
K7B00_RS06685 (K7B00_06685)1297788..1298948-1161WP_229129786.1cellulose synthase complex periplasmic endoglucanase BcsZ-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-92)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10745.15 Da        Isoelectric Point: 7.8253

>T214441 WP_054608787.1 NZ_CP082238:1293564-1293842 [Acidithiobacillus ferrooxidans]
MIKSFRCKDTQSLFEGGAPRRFQGVRPQAERKLLMVDSAKDLKDLKSPPGNGLEKLSGDRKDQWSIRINDQWRICFDWRD
GDAYDVEIVDYH

Download         Length: 279 bp

>T214441 NZ_CP110074:c2783320-2782979 [Enterococcus faecalis]
ATGAATGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGCAAAGAGAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGGCAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11439.21 Da        Isoelectric Point: 10.8303

>AT214441 WP_054608786.1 NZ_CP082238:1293859-1294161 [Acidithiobacillus ferrooxidans]
MTRNRMRPIHPGEVLREEFLAPLGMTPHALAVALRVPSPRINDITRERRAITPDTALRLARYFGTTPEFWMELQSVYDLR
RAEVIAGESISREVTPRQAA

Download         Length: 303 bp

>AT214441 NZ_CP110074:c2783550-2783320 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAACTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References