Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 87342..87950 Replicon chromosome
Accession NZ_CP082238
Organism Acidithiobacillus ferrooxidans strain BYM

Toxin (Protein)


Gene name higB Uniprot ID A0A2W1K1W3
Locus tag K7B00_RS00440 Protein ID WP_012535782.1
Coordinates 87342..87617 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag K7B00_RS00445 Protein ID WP_009566298.1
Coordinates 87633..87950 (+) Length 106 a.a.

Genomic Context

K7B00_RS00405K7B00_RS00410K7B00_RS00415K7B00_RS00425K7B00_RS00430K7B00_RS00435K7B00_RS00440K7B00_RS00445K7B00_RS00450K7B00_RS00455K7B00_RS00460K7B00_RS00465K7B00_RS00470K7B00_RS00475K7B00_RS00480
Location: 83120..84160 (1041 bp)
Type: Others
Protein ID: WP_012535779.1
Location: 84228..85154 (927 bp)
Type: Others
Protein ID: WP_012535780.1
Location: 85147..85515 (369 bp)
Type: Others
Protein ID: WP_012535781.1
Location: 86255..86476 (222 bp)
Type: Others
Protein ID: WP_009566302.1
Location: 86476..86889 (414 bp)
Type: Others
Protein ID: WP_009566301.1
Location: 86886..87176 (291 bp)
Type: Others
Protein ID: WP_009566300.1
Location: 87342..87617 (276 bp)
Type: Toxin
Protein ID: WP_012535782.1
Location: 87633..87950 (318 bp)
Type: Antitoxin
Protein ID: WP_009566298.1
Location: 87965..88144 (180 bp)
Type: Others
Protein ID: WP_009566297.1
Location: 88564..89727 (1164 bp)
Type: Others
Protein ID: WP_009566294.1
Location: 90024..90290 (267 bp)
Type: Others
Protein ID: WP_196491178.1
Location: 90287..90529 (243 bp)
Type: Others
Protein ID: WP_012535785.1
Location: 90613..90786 (174 bp)
Type: Others
Protein ID: WP_009562770.1
Location: 90897..91325 (429 bp)
Type: Others
Protein ID: WP_009562768.1
Location: 91328..91759 (432 bp)
Type: Others
Protein ID: WP_009562767.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K7B00_RS00405 (K7B00_00405)83120..84160+1041WP_012535779.1glycosyltransferase family 1 protein-
K7B00_RS00410 (K7B00_00410)84228..85154+927WP_012535780.1glycosyltransferase-
K7B00_RS00415 (K7B00_00415)85147..85515+369WP_012535781.1glycosyltransferase-
K7B00_RS00425 (K7B00_00425)86255..86476+222WP_009566302.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K7B00_RS00430 (K7B00_00430)86476..86889+414WP_009566301.1type II toxin-antitoxin system VapC family toxin-
K7B00_RS00435 (K7B00_00435)86886..87176+291WP_009566300.1hypothetical protein-
K7B00_RS00440 (K7B00_00440)87342..87617+276WP_012535782.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K7B00_RS00445 (K7B00_00445)87633..87950+318WP_009566298.1HigA family addiction module antitoxinAntitoxin
K7B00_RS00450 (K7B00_00450)87965..88144+180WP_009566297.1HNH endonuclease-
K7B00_RS00455 (K7B00_00455)88564..89727+1164WP_009566294.1Fic family protein-
K7B00_RS00460 (K7B00_00460)90024..90290-267WP_196491178.1hypothetical protein-
K7B00_RS00465 (K7B00_00465)90287..90529-243WP_012535785.1type II toxin-antitoxin system prevent-host-death family antitoxin-
K7B00_RS00470 (K7B00_00470)90613..90786-174WP_009562770.1PCP reductase family protein-
K7B00_RS00475 (K7B00_00475)90897..91325-429WP_009562768.1hypothetical protein-
K7B00_RS00480 (K7B00_00480)91328..91759-432WP_009562767.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-69)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10433.84 Da        Isoelectric Point: 7.9070

>T214437 WP_012535782.1 NZ_CP082238:87342-87617 [Acidithiobacillus ferrooxidans]
MIRSFVHKGLKQVFETGQSAKVGADLVTRCKRRLDAINAATSPEELNVPGFDFHALEGKPKRYTVHVNGPYCITFEWREG
DAWRIDLENYH

Download         Length: 276 bp

>T214437 NZ_CP110074:571113-571229 [Enterococcus faecalis]
ATGTTGTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTAGTTTTGCAATACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11756.54 Da        Isoelectric Point: 5.6631

>AT214437 WP_009566298.1 NZ_CP082238:87633-87950 [Acidithiobacillus ferrooxidans]
MDEMTVEQVDRIPTHPGEILREEVLPALDISVAEFARGLRVSRQTVHGILSERKGITPEMALRIGKYLGNGPGIWLRMQQ
AYDLTVAERRLAEELAAIHKPEQAA

Download         Length: 318 bp

>AT214437 NZ_CP110074:c571345-571140 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTATTGCAAAACTAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2W1K1W3

Antitoxin

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Source
ID
Structure
No matching records found

References