Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 4130805..4131459 Replicon chromosome
Accession NZ_CP082236
Organism Pseudomonas sp. SC3(2021)

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K5Y35_RS18470 Protein ID WP_123462954.1
Coordinates 4131109..4131459 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K5Y35_RS18465 Protein ID WP_123462457.1
Coordinates 4130805..4131119 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5Y35_RS18445 4127171..4127371 + 201 WP_222832557.1 co-regulatory protein PtrA N-terminal domain-containing protein -
K5Y35_RS18450 4127438..4127770 + 333 WP_222832559.1 DUF2790 domain-containing protein -
K5Y35_RS18455 4127940..4129127 - 1188 WP_222832560.1 acyltransferase -
K5Y35_RS18460 4129305..4130630 - 1326 WP_222832561.1 OprD family porin -
K5Y35_RS18465 4130805..4131119 - 315 WP_123462457.1 transcriptional regulator Antitoxin
K5Y35_RS18470 4131109..4131459 - 351 WP_123462954.1 toxin Toxin
K5Y35_RS18475 4132038..4133501 - 1464 WP_007920173.1 NADH-quinone oxidoreductase subunit NuoN -
K5Y35_RS18480 4133509..4135041 - 1533 WP_016986254.1 NADH-quinone oxidoreductase subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(46-100)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13906.75 Da        Isoelectric Point: 8.3986

>T214432 WP_123462954.1 NZ_CP082236:c4131459-4131109 [Pseudomonas sp. SC3(2021)]
MDALFIELPVFQKHRDDYLDDDLFRSLQLELLKNPEAGDLIEDTGGLRKIRFSDQRRGKGKRSGLRVIYYWWSGFDQFWL
FTVYSKNEQDNLTPAQKKLFRKTLDKELNARTHYET

Download         Length: 351 bp

>T214432 NZ_CP110072:c2711622-2711347 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11922.81 Da        Isoelectric Point: 9.9896

>AT214432 WP_123462457.1 NZ_CP082236:c4131119-4130805 [Pseudomonas sp. SC3(2021)]
MKRDIFSELMDGLEALADERQGKITLRTHKVQLPKLMPITADEVVAIRQQLNLSRSVFAMYLRTNTRTLENWEQGRATPN
AQATTLIRLVERFPQTIEQLAALT

Download         Length: 315 bp

>AT214432 NZ_CP110072:c2711881-2711615 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References