Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2741059..2741396 Replicon chromosome
Accession NZ_CP082231
Organism Enterococcus faecalis strain E006

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag K4200_RS13375 Protein ID WP_002396786.1
Coordinates 2741059..2741202 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2741134..2741396 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4200_RS13360 2736712..2737344 - 633 WP_002358972.1 RloB family protein -
K4200_RS13365 2737353..2738648 - 1296 WP_010820355.1 ATP-binding protein -
K4200_RS13370 2739110..2740726 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -
K4200_RS13375 2741059..2741202 + 144 WP_002396786.1 putative holin-like toxin Toxin
- 2741134..2741396 - 263 - - Antitoxin
K4200_RS13380 2741397..2746088 - 4692 WP_070416060.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T214420 WP_002396786.1 NZ_CP082231:2741059-2741202 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

>T214420 NZ_CP110071:404139-404240 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 263 bp

>AT214420 NZ_CP082231:c2741396-2741134 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGTGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTTAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References