Detailed information of TA system TA214416

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2655371..2655645
• Replicon: chromosome
• Accession: NZ_CP082231
• Organism: Enterococcus faecalis strain E006

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: K4200_RS12990
• Protein ID: WP_002392696.1
• Coordinates: 2655502..2655645 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2655371..2655569 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K4200_RS12970	2650373..2651086	-	714	WP_002354877.1	trehalose operon repressor	-
K4200_RS12975	2651348..2654092	+	2745	WP_070416068.1	glycosyl hydrolase family 65 protein	-
K4200_RS12980	2654107..2654757	+	651	WP_002354875.1	beta-phosphoglucomutase	-
K4200_RS12985	2655127..2655231	-	105	WP_023894767.1	putative holin-like toxin	-
-	2655371..2655569	+	199	-	-	Antitoxin
K4200_RS12990	2655502..2655645	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
K4200_RS12995	2655876..2656847	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
K4200_RS13000	2657022..2657459	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
K4200_RS13005	2657592..2658146	-	555	WP_002354869.1	Maf family protein	-
K4200_RS13010	2658171..2660303	-	2133	WP_070416067.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T214416 WP_002392696.1 NZ_CP082231:c2655645-2655502 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T214416 NZ_CP110070:11925-12200 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCATGCACTAACAGGAAATTATA
TAGGTACACGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA

Antitoxin

Nucleotide

• Length: 199 bp

>AT214416 NZ_CP082231:2655371-2655569 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin