Detailed information of TA system TA214413

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2655127..2655569
• Replicon: chromosome
• Accession: NZ_CP082231
• Organism: Enterococcus faecalis strain E006

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: K4200_RS12985
• Protein ID: WP_023894767.1
• Coordinates: 2655127..2655231 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2655371..2655569 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K4200_RS12970	2650373..2651086	-	714	WP_002354877.1	trehalose operon repressor	-
K4200_RS12975	2651348..2654092	+	2745	WP_070416068.1	glycosyl hydrolase family 65 protein	-
K4200_RS12980	2654107..2654757	+	651	WP_002354875.1	beta-phosphoglucomutase	-
K4200_RS12985	2655127..2655231	-	105	WP_023894767.1	putative holin-like toxin	Toxin
-	2655371..2655569	+	199	-	-	Antitoxin
K4200_RS12990	2655502..2655645	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	-
K4200_RS12995	2655876..2656847	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
K4200_RS13000	2657022..2657459	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
K4200_RS13005	2657592..2658146	-	555	WP_002354869.1	Maf family protein	-
K4200_RS13010	2658171..2660303	-	2133	WP_070416067.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-34)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3799.63 Da
• Isoelectric Point: 10.0079

>T214413 WP_023894767.1 NZ_CP082231:c2655231-2655127 [Enterococcus faecalis]
MSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 105 bp

>T214413 NZ_CP110069:c2647588-2647487 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin

Nucleotide

• Length: 199 bp

>AT214413 NZ_CP082231:2655371-2655569 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin