Detailed information of TA system TA214408

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2586836..2587059
• Replicon: chromosome
• Accession: NZ_CP082231
• Organism: Enterococcus faecalis strain E006

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: K4200_RS12665
• Protein ID: WP_021164442.1
• Coordinates: 2586958..2587059 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2586836..2587021 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K4200_RS12640	2582483..2583436	-	954	WP_002375576.1	siderophore ABC transporter substrate-binding protein	-
K4200_RS12645	2583475..2584230	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
K4200_RS12650	2584227..2585192	-	966	WP_002367415.1	iron chelate uptake ABC transporter family permease subunit	-
K4200_RS12655	2585189..2586136	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
K4200_RS12660	2586321..2586773	+	453	WP_002359057.1	YueI family protein	-
-	2586836..2587021	+	186	-	-	Antitoxin
K4200_RS12665	2586958..2587059	-	102	WP_021164442.1	putative holin-like toxin	Toxin
K4200_RS12670	2587249..2589519	-	2271	WP_070416078.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
K4200_RS12675	2589690..2590190	+	501	WP_023894564.1	cysteine hydrolase family protein	-
K4200_RS12680	2590701..2591597	+	897	WP_002368434.1	YitT family protein	-
K4200_RS12685	2591648..2592046	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3625.38 Da
• Isoelectric Point: 4.5869

>T214408 WP_021164442.1 NZ_CP082231:c2587059-2586958 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T214408 NZ_CP110069:388964-389272 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGACAACCAGGATCAGGGAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAAACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACATGCAACATCCTATTCTAATCAGCTGGTAAAGCTTAATTAG

Antitoxin

Nucleotide

• Length: 186 bp

>AT214408 NZ_CP082231:2586836-2587021 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAACGCAACAAGGGTTGCA

Structures

Antitoxin