Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 12489..13147 Replicon plasmid p2018HLJAB2
Accession NZ_CP082228
Organism Acinetobacter baumannii strain 2018HLJAB2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H1I67_RS18935 Protein ID WP_000312250.1
Coordinates 12788..13147 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H1I67_RS18930 Protein ID WP_001096429.1
Coordinates 12489..12788 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1I67_RS18895 7655..8284 + 630 WP_002081923.1 hypothetical protein -
H1I67_RS18900 8324..8833 + 510 WP_001043199.1 hypothetical protein -
H1I67_RS18905 8915..9427 + 513 WP_000840065.1 hypothetical protein -
H1I67_RS18910 9483..9812 + 330 WP_000459117.1 hypothetical protein -
H1I67_RS18915 9849..10577 + 729 WP_001022819.1 hypothetical protein -
H1I67_RS19395 10812..10946 + 135 WP_256349227.1 hypothetical protein -
H1I67_RS18920 11006..11365 + 360 WP_223234021.1 hypothetical protein -
H1I67_RS18925 11415..11855 + 441 WP_228737256.1 hypothetical protein -
H1I67_RS18930 12489..12788 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
H1I67_RS18935 12788..13147 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H1I67_RS18940 13348..13914 + 567 WP_031948745.1 hypothetical protein -
H1I67_RS18945 13963..14145 + 183 WP_000373384.1 hypothetical protein -
H1I67_RS18950 14212..14910 + 699 WP_000873188.1 hypothetical protein -
H1I67_RS18955 15049..15432 + 384 WP_000654347.1 hypothetical protein -
H1I67_RS18960 15499..16257 + 759 WP_060853650.1 hypothetical protein -
H1I67_RS18965 16309..16644 + 336 WP_000654055.1 hypothetical protein -
H1I67_RS18970 17509..17823 + 315 WP_000708713.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-23 - 1..78030 78030


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T214398 WP_000312250.1 NZ_CP082228:c13147-12788 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T214398 NZ_CP110066:c23814-22951 [Enterococcus faecalis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGCTTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAGTTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGGTATGAA
ACTATGTATGCAGATGATCCAATGACAGCTAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGATTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAATACCTAAACTTCCAGGTATTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT214398 WP_001096429.1 NZ_CP082228:c12788-12489 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT214398 NZ_CP110066:c24088-23816 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCATTCATGAGTATTGGCGGGCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References