Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 12439..13097 Replicon plasmid p2016BJAB1
Accession NZ_CP082226
Organism Acinetobacter baumannii strain 2016BJAB1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H1I69_RS18785 Protein ID WP_000312250.1
Coordinates 12738..13097 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H1I69_RS18780 Protein ID WP_001096429.1
Coordinates 12439..12738 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1I69_RS18740 7619..7978 + 360 WP_225371108.1 hypothetical protein -
H1I69_RS18745 8052..8246 + 195 WP_225463233.1 hypothetical protein -
H1I69_RS18750 8426..8734 + 309 WP_228912065.1 hypothetical protein -
H1I69_RS18755 8875..9276 + 402 WP_225371111.1 hypothetical protein -
H1I69_RS18760 9466..9750 + 285 WP_225371112.1 hypothetical protein -
H1I69_RS18765 9823..10530 + 708 WP_225370910.1 hypothetical protein -
H1I69_RS18770 10958..11317 + 360 WP_223234021.1 hypothetical protein -
H1I69_RS18775 11367..11597 + 231 WP_225371113.1 hypothetical protein -
H1I69_RS18780 12439..12738 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
H1I69_RS18785 12738..13097 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H1I69_RS18790 13297..13620 + 324 WP_225371115.1 hypothetical protein -
H1I69_RS18795 13683..13862 + 180 WP_223237436.1 hypothetical protein -
H1I69_RS18800 13911..14093 + 183 WP_000373384.1 hypothetical protein -
H1I69_RS18805 14160..14450 + 291 WP_225371116.1 hypothetical protein -
H1I69_RS18810 15118..15375 + 258 WP_225371117.1 hypothetical protein -
H1I69_RS18815 15442..16200 + 759 WP_060853650.1 hypothetical protein -
H1I69_RS18820 16252..16587 + 336 WP_000654055.1 hypothetical protein -
H1I69_RS18825 17452..17766 + 315 WP_000708713.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-23 - 1..77943 77943


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T214397 WP_000312250.1 NZ_CP082226:c13097-12738 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T214397 NZ_CP110065:21986-22087 [Enterococcus faecalis]
GTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGTGTTGGACGA
GGAAGACGATAGCCGAAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT214397 WP_001096429.1 NZ_CP082226:c12738-12439 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT214397 NZ_CP110065:c22191-22127 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References