Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 12430..13088 Replicon plasmid p2018BJAB1
Accession NZ_CP082220
Organism Acinetobacter baumannii strain 2018BJAB1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H1I75_RS18870 Protein ID WP_000312250.1
Coordinates 12729..13088 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H1I75_RS18865 Protein ID WP_001096429.1
Coordinates 12430..12729 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1I75_RS18830 7597..8226 + 630 WP_002081923.1 hypothetical protein -
H1I75_RS18835 8266..8775 + 510 WP_001043199.1 hypothetical protein -
H1I75_RS18840 8857..9369 + 513 WP_000840065.1 hypothetical protein -
H1I75_RS18845 9425..9754 + 330 WP_000459117.1 hypothetical protein -
H1I75_RS18850 9791..10519 + 729 WP_001022819.1 hypothetical protein -
H1I75_RS18855 10948..11307 + 360 WP_223234021.1 hypothetical protein -
H1I75_RS18860 11357..11893 + 537 WP_060853649.1 hypothetical protein -
H1I75_RS18865 12430..12729 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
H1I75_RS18870 12729..13088 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H1I75_RS18875 13289..13855 + 567 WP_031948745.1 hypothetical protein -
H1I75_RS18880 13904..14086 + 183 WP_000373384.1 hypothetical protein -
H1I75_RS18885 14153..14851 + 699 WP_000873188.1 hypothetical protein -
H1I75_RS18890 14990..15373 + 384 WP_000654347.1 hypothetical protein -
H1I75_RS18895 15440..15589 + 150 WP_229077898.1 hypothetical protein -
H1I75_RS18900 15678..16199 + 522 WP_229077899.1 hypothetical protein -
H1I75_RS18905 16251..16586 + 336 WP_000654055.1 hypothetical protein -
H1I75_RS18910 17451..17765 + 315 WP_000708713.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-23 - 1..78024 78024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T214395 WP_000312250.1 NZ_CP082220:c13088-12729 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T214395 NZ_CP110063:2815930-2816070 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT214395 WP_001096429.1 NZ_CP082220:c12729-12430 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT214395 NZ_CP110063:c2816204-2816003 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References