Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 11559..12217 Replicon plasmid p2018BJAB2
Accession NZ_CP082219
Organism Acinetobacter baumannii strain 2018BJAB2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H1I76_RS19205 Protein ID WP_000312250.1
Coordinates 11858..12217 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H1I76_RS19200 Protein ID WP_001096429.1
Coordinates 11559..11858 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1I76_RS19165 6726..7355 + 630 WP_002081923.1 hypothetical protein -
H1I76_RS19170 7395..7904 + 510 WP_001043199.1 hypothetical protein -
H1I76_RS19175 7986..8498 + 513 WP_000840065.1 hypothetical protein -
H1I76_RS19180 8554..8883 + 330 WP_000459117.1 hypothetical protein -
H1I76_RS19185 8920..9648 + 729 WP_001022819.1 hypothetical protein -
H1I76_RS19655 9883..10017 + 135 WP_256349227.1 hypothetical protein -
H1I76_RS19190 10077..10436 + 360 WP_223234021.1 hypothetical protein -
H1I76_RS19195 10486..11022 + 537 WP_060853649.1 hypothetical protein -
H1I76_RS19200 11559..11858 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
H1I76_RS19205 11858..12217 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H1I76_RS19210 12418..12984 + 567 WP_031948745.1 hypothetical protein -
H1I76_RS19215 13033..13215 + 183 WP_000373384.1 hypothetical protein -
H1I76_RS19220 13282..13980 + 699 WP_000873188.1 hypothetical protein -
H1I76_RS19225 14119..14502 + 384 WP_000654347.1 hypothetical protein -
H1I76_RS19230 14569..15327 + 759 WP_060853650.1 hypothetical protein -
H1I76_RS19235 15379..15714 + 336 WP_000654055.1 hypothetical protein -
H1I76_RS19240 16579..16893 + 315 WP_000708713.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-23 - 1..78023 78023


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T214394 WP_000312250.1 NZ_CP082219:c12217-11858 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T214394 NZ_CP110063:2815930-2816070 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT214394 WP_001096429.1 NZ_CP082219:c11858-11559 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT214394 NZ_CP110063:c2815928-2815785 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References