Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2520320..2520907 Replicon chromosome
Accession NZ_CP082218
Organism Xanthomonas cucurbitae strain IL_234

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K6979_RS10490 Protein ID WP_104604442.1
Coordinates 2520629..2520907 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6979_RS10485 Protein ID WP_104604432.1
Coordinates 2520320..2520619 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6979_RS10470 (K6979_10440) 2516949..2517590 - 642 WP_104605218.1 S41 family peptidase -
K6979_RS10475 (K6979_10445) 2517692..2519241 + 1550 Protein_2066 IS3 family transposase -
K6979_RS10480 (K6979_10450) 2519266..2520168 - 903 WP_146090341.1 hypothetical protein -
K6979_RS10485 (K6979_10455) 2520320..2520619 - 300 WP_104604432.1 HigA family addiction module antitoxin Antitoxin
K6979_RS10490 (K6979_10460) 2520629..2520907 - 279 WP_104604442.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6979_RS10495 (K6979_10465) 2521229..2521969 + 741 WP_104604430.1 flagellar motor protein -
K6979_RS10500 (K6979_10470) 2521977..2522951 + 975 WP_104604428.1 flagellar motor protein MotD -
K6979_RS10505 (K6979_10475) 2522953..2523735 + 783 WP_104604426.1 ParA family protein -
K6979_RS10510 (K6979_10480) 2523732..2524784 + 1053 WP_104604424.1 chemotaxis protein CheW -
K6979_RS10515 (K6979_10485) 2524899..2525207 + 309 WP_104604422.1 STAS domain-containing protein -
K6979_RS10520 (K6979_10490) 2525204..2525569 + 366 WP_002806565.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10657.05 Da        Isoelectric Point: 7.9150

>T214392 WP_104604442.1 NZ_CP082218:c2520907-2520629 [Xanthomonas cucurbitae]
MIQSFRCRHTRALFEGGNPRQFHSMQAAAERKLQLLDSAQTLEFLRSPPGNRLELLSGTRAGQHSIRINDQWRVCFVWTD
AGPEYVEIVDYH

Download         Length: 279 bp

>T214392 NZ_CP110063:c2810222-2809881 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCAAGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10801.44 Da        Isoelectric Point: 10.7850

>AT214392 WP_104604432.1 NZ_CP082218:c2520619-2520320 [Xanthomonas cucurbitae]
MRPTNKLRAIHPGEILREDFMLPLQLTINGLARALDVPATRVHGIVHGARAITADTAARLARHFGGDAASWLALQATYDL
KTLPNRSEIETNVQPRVAA

Download         Length: 300 bp

>AT214392 NZ_CP110063:c2810452-2810222 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GCCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References