Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 86963..87552 Replicon chromosome
Accession NZ_CP082218
Organism Xanthomonas cucurbitae strain IL_234

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag K6979_RS00355 Protein ID WP_104603499.1
Coordinates 86963..87244 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6979_RS00360 Protein ID WP_104603498.1
Coordinates 87262..87552 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6979_RS00350 (K6979_00355) 84679..86865 + 2187 WP_104603500.1 exodeoxyribonuclease V subunit alpha -
K6979_RS00355 (K6979_00360) 86963..87244 + 282 WP_104603499.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6979_RS00360 (K6979_00365) 87262..87552 + 291 WP_104603498.1 HigA family addiction module antitoxin Antitoxin
K6979_RS00365 (K6979_00370) 87561..87713 - 153 WP_274393848.1 hypothetical protein -
K6979_RS00370 87824..88005 - 182 Protein_73 hypothetical protein -
K6979_RS00375 (K6979_00375) 88521..89054 + 534 WP_211292995.1 DUF3800 domain-containing protein -
K6979_RS00380 (K6979_00380) 89259..89591 - 333 WP_104603496.1 hypothetical protein -
K6979_RS00385 (K6979_00385) 90191..90520 + 330 WP_104603495.1 DUF1778 domain-containing protein -
K6979_RS00390 (K6979_00390) 90468..91013 + 546 WP_104603494.1 GNAT family N-acetyltransferase -
K6979_RS00395 (K6979_00395) 91080..91283 + 204 Protein_78 IS4 family transposase -
K6979_RS00400 (K6979_00400) 91334..92134 - 801 WP_274393849.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11012.71 Da        Isoelectric Point: 10.2909

>T214389 WP_104603499.1 NZ_CP082218:86963-87244 [Xanthomonas cucurbitae]
MIRSFIDKEAERIWLGERSRRLPADIQPVARRKLRMLNAAAHLDDLRIPPANRLEALKGARRGQYSIRINDQWRICFRWM
EGDAAEVEIVDYH

Download         Length: 282 bp

>T214389 NZ_CP110063:563057-563173 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10464.13 Da        Isoelectric Point: 7.2043

>AT214389 WP_104603498.1 NZ_CP082218:87262-87552 [Xanthomonas cucurbitae]
MTVLPNIHPGEILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEQA
HRALGDLPSRIKRLAA

Download         Length: 291 bp

>AT214389 NZ_CP110063:c563289-563084 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References