Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2520227..2520814 Replicon chromosome
Accession NZ_CP082217
Organism Xanthomonas cucurbitae strain KS_456

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K6980_RS10500 Protein ID WP_104604442.1
Coordinates 2520536..2520814 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6980_RS10495 Protein ID WP_104604432.1
Coordinates 2520227..2520526 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6980_RS10480 (K6980_10435) 2516856..2517497 - 642 WP_104605218.1 S41 family peptidase -
K6980_RS10485 (K6980_10440) 2517599..2519148 + 1550 Protein_2068 IS3 family transposase -
K6980_RS10490 (K6980_10445) 2519173..2520108 - 936 WP_104604434.1 hypothetical protein -
K6980_RS10495 (K6980_10450) 2520227..2520526 - 300 WP_104604432.1 HigA family addiction module antitoxin Antitoxin
K6980_RS10500 (K6980_10455) 2520536..2520814 - 279 WP_104604442.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6980_RS10505 (K6980_10460) 2521136..2521876 + 741 WP_104604430.1 flagellar motor protein -
K6980_RS10510 (K6980_10465) 2521884..2522858 + 975 WP_104604428.1 flagellar motor protein MotD -
K6980_RS10515 (K6980_10470) 2522860..2523642 + 783 WP_104604426.1 ParA family protein -
K6980_RS10520 (K6980_10475) 2523639..2524691 + 1053 WP_104604424.1 chemotaxis protein CheW -
K6980_RS10525 (K6980_10480) 2524806..2525114 + 309 WP_104604422.1 STAS domain-containing protein -
K6980_RS10530 (K6980_10485) 2525111..2525476 + 366 WP_002806565.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10657.05 Da        Isoelectric Point: 7.9150

>T214387 WP_104604442.1 NZ_CP082217:c2520814-2520536 [Xanthomonas cucurbitae]
MIQSFRCRHTRALFEGGNPRQFHSMQAAAERKLQLLDSAQTLEFLRSPPGNRLELLSGTRAGQHSIRINDQWRVCFVWTD
AGPEYVEIVDYH

Download         Length: 279 bp

>T214387 NZ_CP110060:87711-87986 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAATT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10801.44 Da        Isoelectric Point: 10.7850

>AT214387 WP_104604432.1 NZ_CP082217:c2520526-2520227 [Xanthomonas cucurbitae]
MRPTNKLRAIHPGEILREDFMLPLQLTINGLARALDVPATRVHGIVHGARAITADTAARLARHFGGDAASWLALQATYDL
KTLPNRSEIETNVQPRVAA

Download         Length: 300 bp

>AT214387 NZ_CP110060:87452-87718 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References