Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1901440..1901955 Replicon chromosome
Accession NZ_CP082215
Organism Xanthomonas cucurbitae strain MI_359

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag K6982_RS08145 Protein ID WP_167526871.1
Coordinates 1901440..1901646 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6982_RS08150 Protein ID WP_159406979.1
Coordinates 1901656..1901955 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6982_RS08115 (K6982_08085) 1896542..1896907 - 366 WP_002806565.1 response regulator -
K6982_RS08120 (K6982_08090) 1896904..1897212 - 309 WP_104604422.1 STAS domain-containing protein -
K6982_RS08125 (K6982_08095) 1897327..1898541 - 1215 WP_159406977.1 chemotaxis protein CheW -
K6982_RS08130 (K6982_08100) 1898538..1899320 - 783 WP_159406978.1 ParA family protein -
K6982_RS08135 (K6982_08105) 1899322..1900296 - 975 WP_104604428.1 flagellar motor protein MotD -
K6982_RS08140 (K6982_08110) 1900304..1901044 - 741 WP_104604430.1 flagellar motor protein -
K6982_RS08145 (K6982_08115) 1901440..1901646 + 207 WP_167526871.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6982_RS08150 (K6982_08120) 1901656..1901955 + 300 WP_159406979.1 HigA family addiction module antitoxin Antitoxin
K6982_RS08155 (K6982_08125) 1902107..1903705 + 1599 WP_159406980.1 S41 family peptidase -
K6982_RS08160 (K6982_08130) 1903986..1904771 - 786 WP_126942758.1 hypothetical protein -
K6982_RS08165 (K6982_08135) 1904755..1905294 - 540 WP_223214429.1 HNH endonuclease signature motif containing protein -
K6982_RS08170 (K6982_08140) 1905390..1906406 - 1017 WP_159406982.1 IS30 family transposase -
K6982_RS08175 (K6982_08145) 1906382..1906765 - 384 WP_159406983.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cheY 1712118..1956071 243953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-68)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-83)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7668.74 Da        Isoelectric Point: 7.2776

>T214380 WP_167526871.1 NZ_CP082215:1901440-1901646 [Xanthomonas cucurbitae]
MQAAAERKLQLLDSAQTLEFLRSPPANRLELLAGTRVGQHSIRINDQWRVCFVWTGAGPGHVEIVDYH

Download         Length: 207 bp

>T214380 NZ_CP082215:1901440-1901646 [Xanthomonas cucurbitae]
ATGCAGGCCGCAGCCGAGCGGAAGCTGCAGTTGCTGGATTCGGCGCAGACGCTGGAGTTCTTGCGCAGTCCGCCAGCCAA
TCGGCTTGAGCTTCTTGCAGGTACGCGTGTAGGTCAGCACAGCATCCGCATCAACGACCAATGGCGTGTGTGCTTTGTCT
GGACCGGTGCCGGCCCTGGGCACGTAGAGATTGTTGACTATCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10831.47 Da        Isoelectric Point: 10.7850

>AT214380 WP_159406979.1 NZ_CP082215:1901656-1901955 [Xanthomonas cucurbitae]
MRPTNKLRAIHPGEILREDFMLPLQLTINGLARALDVPATRVHSIVHGARAITADTAARLARHFGGDAASWLALQATYDL
KTLPNRSEIETNVQPRVAA

Download         Length: 300 bp

>AT214380 NZ_CP082215:1901656-1901955 [Xanthomonas cucurbitae]
ATGCGACCCACCAACAAGCTGCGCGCGATCCATCCCGGCGAGATCCTGCGCGAGGACTTCATGCTGCCATTGCAGCTGAC
CATCAACGGCCTGGCGCGTGCGTTGGATGTGCCTGCCACGCGCGTCCACAGCATCGTGCACGGCGCGCGCGCGATCACTG
CCGATACCGCTGCGCGCCTTGCGCGTCACTTCGGTGGCGACGCGGCATCCTGGCTTGCGCTGCAGGCCACTTACGACCTG
AAGACCTTGCCCAACCGTAGTGAGATCGAGACCAACGTGCAGCCGCGTGTAGCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References