Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 92044..92633 Replicon chromosome
Accession NZ_CP082215
Organism Xanthomonas cucurbitae strain MI_359

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag K6982_RS00380 Protein ID WP_104603499.1
Coordinates 92044..92325 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6982_RS00385 Protein ID WP_104603498.1
Coordinates 92343..92633 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6982_RS00375 (K6982_00380) 89760..91946 + 2187 WP_159406426.1 exodeoxyribonuclease V subunit alpha -
K6982_RS00380 (K6982_00385) 92044..92325 + 282 WP_104603499.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6982_RS00385 (K6982_00390) 92343..92633 + 291 WP_104603498.1 HigA family addiction module antitoxin Antitoxin
K6982_RS00390 (K6982_00395) 92642..92794 - 153 WP_274392027.1 hypothetical protein -
K6982_RS00395 92905..93086 - 182 Protein_78 hypothetical protein -
K6982_RS00400 (K6982_00400) 93601..94134 + 534 WP_208800435.1 DUF3800 domain-containing protein -
K6982_RS00405 (K6982_00405) 94339..94671 - 333 WP_104603496.1 hypothetical protein -
K6982_RS00410 (K6982_00410) 95271..95600 + 330 WP_159406427.1 DUF1778 domain-containing protein -
K6982_RS00415 (K6982_00415) 95548..96093 + 546 WP_159406428.1 GNAT family N-acetyltransferase -
K6982_RS00420 (K6982_00420) 96160..96363 + 204 Protein_83 IS4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 80226..96093 15867


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11012.71 Da        Isoelectric Point: 10.2909

>T214379 WP_104603499.1 NZ_CP082215:92044-92325 [Xanthomonas cucurbitae]
MIRSFIDKEAERIWLGERSRRLPADIQPVARRKLRMLNAAAHLDDLRIPPANRLEALKGARRGQYSIRINDQWRICFRWM
EGDAAEVEIVDYH

Download         Length: 282 bp

>T214379 NZ_CP110059:c2619324-2619223 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10464.13 Da        Isoelectric Point: 7.2043

>AT214379 WP_104603498.1 NZ_CP082215:92343-92633 [Xanthomonas cucurbitae]
MTVLPNIHPGEILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEQA
HRALGDLPSRIKRLAA

Download         Length: 291 bp

>AT214379 NZ_CP110059:2619101-2619278 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References