Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4471981..4472570 Replicon chromosome
Accession NZ_CP082214
Organism Xanthomonas cucurbitae strain OH_261

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag K6978_RS19480 Protein ID WP_104603499.1
Coordinates 4472289..4472570 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6978_RS19475 Protein ID WP_104603498.1
Coordinates 4471981..4472271 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6978_RS19440 (K6978_19355) 4467228..4468028 + 801 WP_274393849.1 hypothetical protein -
K6978_RS19445 (K6978_19360) 4468079..4468282 - 204 Protein_3823 IS4 family transposase -
K6978_RS19450 (K6978_19365) 4468349..4468894 - 546 WP_159406428.1 GNAT family N-acetyltransferase -
K6978_RS19455 (K6978_19370) 4468842..4469171 - 330 WP_159406427.1 DUF1778 domain-containing protein -
K6978_RS19460 (K6978_19375) 4469771..4470103 + 333 WP_104603496.1 hypothetical protein -
K6978_RS19465 (K6978_19380) 4470308..4471204 - 897 WP_274396650.1 DUF3800 domain-containing protein -
K6978_RS19470 4471528..4471709 + 182 Protein_3828 hypothetical protein -
K6978_RS19475 (K6978_19385) 4471981..4472271 - 291 WP_104603498.1 HigA family addiction module antitoxin Antitoxin
K6978_RS19480 (K6978_19390) 4472289..4472570 - 282 WP_104603499.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6978_RS19485 (K6978_19395) 4472668..4474854 - 2187 WP_274396651.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11012.71 Da        Isoelectric Point: 10.2909

>T214378 WP_104603499.1 NZ_CP082214:c4472570-4472289 [Xanthomonas cucurbitae]
MIRSFIDKEAERIWLGERSRRLPADIQPVARRKLRMLNAAAHLDDLRIPPANRLEALKGARRGQYSIRINDQWRICFRWM
EGDAAEVEIVDYH

Download         Length: 282 bp

>T214378 NZ_CP110059:c1492982-1492638 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTCTCCCATTCGGATTATATTGAGTTATATAAAATTCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCAGATTAT
CATATGTTTAAATGTCTTATTGAAAAACATGACGGGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10464.13 Da        Isoelectric Point: 7.2043

>AT214378 WP_104603498.1 NZ_CP082214:c4472271-4471981 [Xanthomonas cucurbitae]
MTVLPNIHPGEILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEQA
HRALGDLPSRIKRLAA

Download         Length: 291 bp

>AT214378 NZ_CP110059:c1493331-1492999 [Enterococcus faecalis]
ATGAACCTCTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTATTTGAAAGGGAG
ATTCGGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References