Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1967665..1968252 Replicon chromosome
Accession NZ_CP082214
Organism Xanthomonas cucurbitae strain OH_261

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K6978_RS08790 Protein ID WP_104604442.1
Coordinates 1967665..1967943 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6978_RS08795 Protein ID WP_104604432.1
Coordinates 1967953..1968252 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6978_RS08760 (K6978_08745) 1962841..1963206 - 366 WP_002806565.1 response regulator -
K6978_RS08765 (K6978_08750) 1963203..1963511 - 309 WP_104604422.1 STAS domain-containing protein -
K6978_RS08770 (K6978_08755) 1963626..1964840 - 1215 WP_274397114.1 chemotaxis protein CheW -
K6978_RS08775 (K6978_08760) 1964837..1965619 - 783 WP_159406978.1 ParA family protein -
K6978_RS08780 (K6978_08765) 1965621..1966595 - 975 WP_104604428.1 flagellar motor protein MotD -
K6978_RS08785 (K6978_08770) 1966603..1967343 - 741 WP_104604430.1 flagellar motor protein -
K6978_RS08790 (K6978_08775) 1967665..1967943 + 279 WP_104604442.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6978_RS08795 (K6978_08780) 1967953..1968252 + 300 WP_104604432.1 HigA family addiction module antitoxin Antitoxin
K6978_RS08800 (K6978_08785) 1968404..1970002 + 1599 WP_159406980.1 S41 family peptidase -
K6978_RS08805 (K6978_08790) 1970283..1971068 - 786 WP_126942758.1 hypothetical protein -
K6978_RS08810 (K6978_08795) 1971052..1971984 - 933 WP_274397115.1 HNH endonuclease -
K6978_RS08815 (K6978_08800) 1972142..1972834 - 693 WP_274397277.1 HEPN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10657.05 Da        Isoelectric Point: 7.9150

>T214375 WP_104604442.1 NZ_CP082214:1967665-1967943 [Xanthomonas cucurbitae]
MIQSFRCRHTRALFEGGNPRQFHSMQAAAERKLQLLDSAQTLEFLRSPPGNRLELLSGTRAGQHSIRINDQWRVCFVWTD
AGPEYVEIVDYH

Download         Length: 279 bp

>T214375 NZ_CP110056:23697-23972 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAATT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10801.44 Da        Isoelectric Point: 10.7850

>AT214375 WP_104604432.1 NZ_CP082214:1967953-1968252 [Xanthomonas cucurbitae]
MRPTNKLRAIHPGEILREDFMLPLQLTINGLARALDVPATRVHGIVHGARAITADTAARLARHFGGDAASWLALQATYDL
KTLPNRSEIETNVQPRVAA

Download         Length: 300 bp

>AT214375 NZ_CP110056:23438-23704 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References