Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4474707..4475296 Replicon chromosome
Accession NZ_CP082213
Organism Xanthomonas cucurbitae strain WI_206

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag K6981_RS19500 Protein ID WP_104603499.1
Coordinates 4475015..4475296 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6981_RS19495 Protein ID WP_104603498.1
Coordinates 4474707..4474997 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6981_RS19460 (K6981_19390) 4469954..4470754 + 801 WP_274393849.1 hypothetical protein -
K6981_RS19465 (K6981_19395) 4470805..4471008 - 204 Protein_3827 IS4 family transposase -
K6981_RS19470 (K6981_19400) 4471075..4471620 - 546 WP_159406428.1 GNAT family N-acetyltransferase -
K6981_RS19475 (K6981_19405) 4471568..4471897 - 330 WP_159406427.1 DUF1778 domain-containing protein -
K6981_RS19480 (K6981_19410) 4472497..4472829 + 333 WP_104603496.1 hypothetical protein -
K6981_RS19485 (K6981_19415) 4473034..4473930 - 897 WP_274396650.1 DUF3800 domain-containing protein -
K6981_RS19490 4474254..4474435 + 182 Protein_3832 hypothetical protein -
K6981_RS19495 (K6981_19420) 4474707..4474997 - 291 WP_104603498.1 HigA family addiction module antitoxin Antitoxin
K6981_RS19500 (K6981_19425) 4475015..4475296 - 282 WP_104603499.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6981_RS19505 (K6981_19430) 4475394..4477580 - 2187 WP_274396651.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11012.71 Da        Isoelectric Point: 10.2909

>T214373 WP_104603499.1 NZ_CP082213:c4475296-4475015 [Xanthomonas cucurbitae]
MIRSFIDKEAERIWLGERSRRLPADIQPVARRKLRMLNAAAHLDDLRIPPANRLEALKGARRGQYSIRINDQWRICFRWM
EGDAAEVEIVDYH

Download         Length: 282 bp

>T214373 NZ_CP110054:2759717-2759860 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10464.13 Da        Isoelectric Point: 7.2043

>AT214373 WP_104603498.1 NZ_CP082213:c4474997-4474707 [Xanthomonas cucurbitae]
MTVLPNIHPGEILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEQA
HRALGDLPSRIKRLAA

Download         Length: 291 bp

>AT214373 NZ_CP110054:c2760054-2759792 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGACAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References