Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1970575..1971162 Replicon chromosome
Accession NZ_CP082213
Organism Xanthomonas cucurbitae strain WI_206

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K6981_RS08810 Protein ID WP_104604442.1
Coordinates 1970575..1970853 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6981_RS08815 Protein ID WP_104604432.1
Coordinates 1970863..1971162 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6981_RS08780 (K6981_08775) 1965751..1966116 - 366 WP_002806565.1 response regulator -
K6981_RS08785 (K6981_08780) 1966113..1966421 - 309 WP_104604422.1 STAS domain-containing protein -
K6981_RS08790 (K6981_08785) 1966536..1967750 - 1215 WP_274397114.1 chemotaxis protein CheW -
K6981_RS08795 (K6981_08790) 1967747..1968529 - 783 WP_159406978.1 ParA family protein -
K6981_RS08800 (K6981_08795) 1968531..1969505 - 975 WP_104604428.1 flagellar motor protein MotD -
K6981_RS08805 (K6981_08800) 1969513..1970253 - 741 WP_104604430.1 flagellar motor protein -
K6981_RS08810 (K6981_08805) 1970575..1970853 + 279 WP_104604442.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6981_RS08815 (K6981_08810) 1970863..1971162 + 300 WP_104604432.1 HigA family addiction module antitoxin Antitoxin
K6981_RS08820 (K6981_08815) 1971314..1972912 + 1599 WP_159406980.1 S41 family peptidase -
K6981_RS08825 (K6981_08820) 1973193..1973978 - 786 WP_126942758.1 hypothetical protein -
K6981_RS08830 (K6981_08825) 1973962..1974894 - 933 WP_274397115.1 HNH endonuclease -
K6981_RS08835 (K6981_08830) 1975052..1975951 - 900 WP_274392083.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10657.05 Da        Isoelectric Point: 7.9150

>T214370 WP_104604442.1 NZ_CP082213:1970575-1970853 [Xanthomonas cucurbitae]
MIQSFRCRHTRALFEGGNPRQFHSMQAAAERKLQLLDSAQTLEFLRSPPGNRLELLSGTRAGQHSIRINDQWRVCFVWTD
AGPEYVEIVDYH

Download         Length: 279 bp

>T214370 NZ_CP110054:2759346-2759486 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAGAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10801.44 Da        Isoelectric Point: 10.7850

>AT214370 WP_104604432.1 NZ_CP082213:1970863-1971162 [Xanthomonas cucurbitae]
MRPTNKLRAIHPGEILREDFMLPLQLTINGLARALDVPATRVHGIVHGARAITADTAARLARHFGGDAASWLALQATYDL
KTLPNRSEIETNVQPRVAA

Download         Length: 300 bp

>AT214370 NZ_CP110054:c2759344-2759201 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References