Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 351936..352582 Replicon chromosome
Accession NZ_CP082207
Organism Klebsiella pneumoniae strain KPN43G

Toxin (Protein)


Gene name higB Uniprot ID A0A486RBU5
Locus tag K6032_RS01620 Protein ID WP_032410616.1
Coordinates 351936..352283 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag K6032_RS01625 Protein ID WP_002920557.1
Coordinates 352283..352582 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6032_RS01610 (347862) 347862..349295 + 1434 WP_002920564.1 glycogen synthase GlgA -
K6032_RS01615 (349313) 349313..351760 + 2448 WP_002920561.1 glycogen phosphorylase -
K6032_RS01620 (351936) 351936..352283 + 348 WP_032410616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6032_RS01625 (352283) 352283..352582 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
K6032_RS01630 (352645) 352645..354153 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
K6032_RS01635 (354358) 354358..354687 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
K6032_RS01640 (354738) 354738..355568 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
K6032_RS01645 (355618) 355618..356376 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13545.55 Da        Isoelectric Point: 5.6802

>T214311 WP_032410616.1 NZ_CP082207:351936-352283 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFEPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T214311 NZ_CP110036:203422-203523 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACAATAAAAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT214311 WP_002920557.1 NZ_CP082207:352283-352582 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT214311 NZ_CP110036:c203642-203468 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486RBU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References