Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4034757..4035347 Replicon chromosome
Accession NZ_CP082178
Organism Xanthomonas fragariae strain SHQP01

Toxin (Protein)


Gene name graT Uniprot ID A0A2N7V9W3
Locus tag K4A87_RS19460 Protein ID WP_016902142.1
Coordinates 4035066..4035347 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag K4A87_RS19455 Protein ID WP_002803896.1
Coordinates 4034757..4035047 (-) Length 97 a.a.

Genomic Context

K4A87_RS19445K4A87_RS19450K4A87_RS19435K4A87_RS19440K4A87_RS19455K4A87_RS19460K4A87_RS19465
Location: 4033883..4034215 (333 bp)
Type: Others
Protein ID: WP_208588210.1
Location: 4034376..4034566 (191 bp)
Type: Others
Protein ID: Protein_3601
Location: 4031948..4032853 (906 bp)
Type: Others
Protein ID: WP_208588208.1
Location: 4032916..4033443 (528 bp)
Type: Others
Protein ID: WP_208588209.1
Location: 4034757..4035047 (291 bp)
Type: Antitoxin
Protein ID: WP_002803896.1
Location: 4035066..4035347 (282 bp)
Type: Toxin
Protein ID: WP_016902142.1
Location: 4035809..4037944 (2136 bp)
Type: Others
Protein ID: WP_208588211.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K4A87_RS19435 (K4A87_19295)4031948..4032853-906WP_208588208.1hypothetical protein-
K4A87_RS19440 (K4A87_19300)4032916..4033443-528WP_208588209.1hypothetical protein-
K4A87_RS19445 (K4A87_19305)4033883..4034215+333WP_208588210.1hypothetical protein-
K4A87_RS194504034376..4034566+191Protein_3601hypothetical protein-
K4A87_RS19455 (K4A87_19310)4034757..4035047-291WP_002803896.1HigA family addiction module antitoxinAntitoxin
K4A87_RS19460 (K4A87_19315)4035066..4035347-282WP_016902142.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K4A87_RS19465 (K4A87_19320)4035809..4037944-2136WP_208588211.1exodeoxyribonuclease V subunit alpha-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-94)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11064.75 Da        Isoelectric Point: 9.7972

>T214270 WP_016902142.1 NZ_CP082178:c4035347-4035066 [Xanthomonas fragariae]
MIRSFVDKEAEKIWMGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYH

Download         Length: 282 bp

>T214270 NZ_CP110018:c220343-220065 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10528.25 Da        Isoelectric Point: 7.1667

>AT214270 WP_002803896.1 NZ_CP082178:c4035047-4034757 [Xanthomonas fragariae]
MTVLPNIHPGEILLEEFLEPMGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALCTTERFWLGLQADYELEQA
HRALGDLPSRIKRLAA

Download         Length: 291 bp

>AT214270 NZ_CP110018:c220606-220346 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2N7V9W3

Antitoxin

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Source
ID
Structure
No matching records found

References